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megaloblast
meg·a·lo·blast M0198900 (mĕg′ə-lō-blăst′)n. An abnormally large immature red blood cell (erythroblast) found especially in the blood of people with certain types of anemia and often associated with vitamin B12 deficiency.
meg′a·lo·blas′tic adj.megaloblast (ˈmɛɡələʊˌblɑːst) n (Medicine) an abnormally large red blood cell precursor, present in certain types of anaemia megaloblastic adjmeg•a•lo•blast (ˈmɛg ə ləˌblæst)
n. an abnormally large immature dysfunctional red blood cell found in the blood esp. of persons with pernicious anemia. [1895–1900] meg`a•lo•blas′tic, adj. Thesaurus| Noun | 1. |  megaloblast - abnormally large red blood cell present in pernicious anemia and folic acid deficiencyerythrocyte, RBC, red blood cell - a mature blood cell that contains hemoglobin to carry oxygen to the bodily tissues; a biconcave disc that has no nucleus |
megaloblast
megaloblast[′meg·ə·lō‚blast] (pathology) A large nucleated erythroblast appearing in bone marrow in vitamin B12 or folic acid deficiency. megaloblast
megaloblast [meg´ah-lo-blast″] a large, nucleated immature progenitor of an abnormal series" >erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.meg·a·lo·blast (meg'ă-lō-blast'), A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblasts four stages of development are as follows: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, 4) orthochromatic megaloblast.
See also: erythroblast. [megalo- + G. blastos, + germ, sprout] megaloblast (mĕg′ə-lō-blăst′)n. An abnormally large nucleated red blood cell found especially in people having pernicious anemia or certain vitamin deficiencies.
meg′a·lo·blas′tic adj.megaloblast An enlarged erythroblast (erythrocyte precursor) with an enlarged nucleus, which arises in a background of vitamin B12 and/or folic acid deficiency and is characterised by asynchronous nucleocytoplasmic development, and manifest by delayed or incomplete nuclear maturation relative to cytoplasmic development; haemoglobinisation proceeds normally, while nuclear maturation slows as the maturation-dependent methyl precursors—usually provided by vitamin B12 and folic acid—are not present.meg·a·lo·blast (meg'ă-lō-blast) A large, nucleated, embryonic type of cell that is a precursor of erythrocytes in an abnormal erythropoietic process observed in pernicious anemia; a megaloblast's four stages of development are: 1) promegaloblast, 2) basophilic megaloblast, 3) polychromatic megaloblast, and 4) orthochromatic megaloblast.
See also: erythroblast[megalo- + G. blastos, germ, sprout]MegaloblastA large erythroblast (a red marrow cell that synthesizes hemoglobin).Mentioned in: Anemiasmegaloblast
Related to megaloblast: macrocytic anemia, macrocyte, pernicious anemiaWords related to megaloblastnoun abnormally large red blood cell present in pernicious anemia and folic acid deficiencyRelated Words- erythrocyte
- RBC
- red blood cell
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