megamitochondria

Massively enlarged mitochondria, which are typically seen in alcoholic livers but are also seen in malnutrition, in skeletal muscle with myopathy and in cancer.
Megamitochondria (MG) formation is attributed to free radical formation triggered by ethanol, chloramphenicol and hydrazine, and can be suppressed by free radical scavengers such as alpha-tocopherol and coenzyme Q(10). Continous exposure of cells with MG to free radicals induces apoptosis, a finding which suggests that MG formation is an adaptative process to unfavourable environments at the level of intracellular organelles. Mitochondria try to decrease intracellular reactive oxygen species (ROS) levels by decreasing the oxygen consumption by forming MGs.

单词	megamitochondria
释义	megamitochondria megamitochondria Massively enlarged mitochondria, which are typically seen in alcoholic livers but are also seen in malnutrition, in skeletal muscle with myopathy and in cancer. Megamitochondria (MG) formation is attributed to free radical formation triggered by ethanol, chloramphenicol and hydrazine, and can be suppressed by free radical scavengers such as alpha-tocopherol and coenzyme Q(10). Continous exposure of cells with MG to free radicals induces apoptosis, a finding which suggests that MG formation is an adaptative process to unfavourable environments at the level of intracellular organelles. Mitochondria try to decrease intracellular reactive oxygen species (ROS) levels by decreasing the oxygen consumption by forming MGs.
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