nucleotide-binding oligomerization domain protein


nucleotide-binding oligomerization domain protein

Abbreviation: NOD
Any of a family of cytoplasmic proteins that recognize molecules associated with disease-causing bacteria and stimulate cells to secrete cytokines and costimulatory molecules. Inappropriate regulation of nucleotide-binding oligomerization domain proteins has been linked to the pathogenesis of Crohn's disease and other syndromes. See also: protein