monoclonal gammopathy


mon·o·clo·nal gam·mop·a·thy

any one of a group of disorders due to proliferation of a single clone of lymphoid or plasma cells and characterized by the presence of monoclonal immunoglobulin in serum or urine (visible on electrophoresis as a single peak).

monoclonal gammopathy

A condition characterized by the clonal proliferation of immunoglobulin-producing B cells Monoclonal gammopathy types Malignant Multiple myeloma Variants of multiple myeoloma • Solitary plasmacytoma of bone • Extramedullary plasmacytoma • Plasma cell leukemia • Non-secretory myeloma Lymphoproliferative disorders • Waldenström's macroglobulinemia • Lymphoma Heavy chain disease (γ, α, μ) Amyloidosis Of undetermined significance Benign (IgG, IgA, IgM, IgD, or light chains) Associated neoplasms that rarely produce monoclonal proteins Biclonal gammopathies