low-grade squamous intraepithelial lesion


low-grade squamous intraepithelial lesion (LGSIL, LSIL),

term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effect and mild dysplasia (cervical intraepithelial neoplasia grade 1).
See also: Bethesda system, reactive changes, ASCUS, atypical glandular cells of undetermined significance.

low-grade squamous intraepithelial lesion

Gynecologic cytology A lesion of the uterine cervix which is characterized by cells occurring singly or in sheets, nuclear abnormalities in cells with mature cytoplasm, bi- or multinucleation, well-defined optically clear perinuclear halo, distinct cell borders and others that translate into either HPV infection or mild dysplasia–CIN 1 of uterine cervix–a diagnosis made on biopsied tissue. Cf High-grade squamous intraepithelial lesion.

low-grade squa·mous in·tra·ep·i·the·li·al le·sion

(LGSIL, LSIL) (lō-grād skwā'mŭs in'tră-ep'i-thē'lē-ăl lē'zhŭn) Term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effects and mild dysplasia (cervical intraepithelial neoplasia grade 1).
See also: Bethesda system, reactive changes, ASCUS, atypical glandular cells of undetermined significance

low-grade squamous intraepithelial lesion

Abbreviation: LGSIL
A cytological abnormality found in Papanicolaou tests (Pap tests) where there are early mild changes in the epithelial cells covering the outside of the cervix. Causes include infection with human papillomavirus, cervical trauma, or postmenopausal changes. Risk factors include intercourse with multiple sex partners or a partner with multiple sex partners, unprotected sex at a young age, history of sexually transmitted disease, and tobacco use. About 60% of LGSIL will spontaneously resolve. If left untreated, a small number of women eventually develop cervical cancer. See also: lesion