melphalan

[mel´fah-lan] a cytotoxic alkylating agent derived from nitrogen mustard, used as an antineoplastic agent, primarily for treatment of multiple myeloma; administered orally or intravenously.

melphalan (L-PAM, L-phenylalanine mustard, L-sarcolysin)

Alkeran

melphalan hydrochloride

Alkeran

Pharmacologic class: Alkylator

Therapeutic class: Antineoplastic

Pregnancy risk category D

FDA Box Warning

• Give under supervision of physician experienced in cancer chemotherapy, in facility with adequate diagnostic and treatment resources.

• Drug may cause severe bone marrow suppression leading to infection or bleeding. I.V. use causes greater myelosuppression than oral use, and also may lead to hypersensitivity reactions (including anaphylaxis).

• Drug may cause leukemia and is potentially mutagenic.

Action

Forms cross-links between strands of cellular DNA, disrupting DNA and RNA transcription and causing cell death

Availability

Powder for injection (melphalan hydrochloride): 50 mg

Tablets: 2 mg

Indications and dosages

➣ Multiple myeloma

Adults: Initially, 6 mg P.O. daily for 2 to 3 weeks, then discontinue drug for up to 4 weeks or until white blood cell (WBC) and platelet counts increase; then give maintenance dosage of 2 or 10 mg/day for 7 to 10 days, then withhold until WBC recovery followed by 2 mg/day maintenance or 0.15 mg/kg/day P.O. for 7 days or 0.25 mg/kg for 4 days, repeated q 4 to 6 weeks. For those who can't tolerate oral therapy, 16 mg/m² by I.V. infusion over 15 to 20 minutes at 2-week intervals for four doses (usually with prednisone); I.V. dose can be repeated q 4 weeks after recovery from toxicity.

➣ Nonresectable advanced ovarian cancer

Adults: 0.2 mg/kg/day P.O. for 5 days q 4 to 5 weeks

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to drug

• Patients whose disease has shown previous drug resistance

Precautions

Use cautiously in:

• bone marrow depression, infection, renal disease

• previous radiation therapy

• patients with childbearing potential

• pregnant or breastfeeding patients

• children (safety and efficacy not established).

Administration

• Before starting therapy, obtain CBC with white cell differential and platelet count. Repeat periodically before each course.

• For I.V. use, reconstitute by rapidly injecting 10 ml of supplied diluent into vial with lyophilized powder. Shake until solution is clear (yields a concentration of 5 mg/ml).

• Dilute desired dosage in 0.9% sodium chloride injection to a concentration no greater than 0.45 mg/ml. Administer over 15 minutes, being sure to give entire dose within 60 minutes of reconstitution.

See Minimize time between reconstitution, dilution, and administration, because solution is unstable.

Adverse reactions

CV: hypotension, tachycardia, vasculitis

GI: nausea, vomiting, diarrhea, oral ulcers, stomatitis

GU: hyperuricemia, amenorrhea, gonadal suppression, infertility

Hematologic: anemia, purpura, bone marrow depression, leukopenia, thrombocytopenia

Hepatic: hepatotoxicity

Metabolic: hyperuricemia

Respiratory: dyspnea, interstitial pneumonitis, bronchospasm, fibrosis

Skin: rash, urticaria, pruritus, alopecia, sweating

Other: edema, extravasation at I.V. site, allergic reactions including anaphylaxis

Interactions

Drug-drug. Carmustine: increased pulmonary toxicity

Cimetidine: decreased GI absorption of melphalan

Cisplatin: increased risk of renal dysfunction, decreased melphalan clearance

Cyclosporine: increased risk of nephrotoxicity, severe renal failure

Interferon alfa: decreased melphalan blood level

Live-virus vaccines: decreased antibody response to vaccine

Myelosuppressants: additive toxicity

Nalidixic acid: increased risk of severe hemorrhagic necrotic enterocolitis (in children)

Drug-diagnostic tests. Hemoglobin, platelets, red blood cells, WBCs: decreased values

Nitrogenous compounds: increased levels

Drug-food. Any food: decreased absorption of oral melphalan

Patient monitoring

See Monitor patient for thrombocytopenia and leukopenia. If platelet count exceeds 100,000/mm³ or WBC count is below 3,000/mm³, discontinue drug until peripheral blood counts recover.

See Watch closely for indications of bone marrow depression, including infection, anemia, and bleeding.

See After multiple courses, watch for acute hypersensitivity reaction. If it occurs, discontinue drug and administer volume expanders, corticosteroids, or antihistamines, as prescribed.

• Watch for signs and symptoms of GI or pulmonary toxicity.

• Evaluate renal and hepatic function.

Patient teaching

• Tell patient to take oral tablets without food, because food may decrease drug absorption.

• Instruct patient to take entire daily oral dose at one time on empty stomach.

See Advise patient to immediately report unusual bleeding or bruising, fever, chills, sore throat, shortness of breath, yellowing of skin or eyes, persistent cough, flank or stomach pain, joint pain, black tarry stools, rash, or unusual lumps or masses.

• Tell patient to consult prescriber before using over-the-counter medications.

• Advise patient to use reliable contraception.

• Caution patient to avoid breastfeeding.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

melphalan

An alkylating nitrogen mustard used to treat ovarian cancer, myeloma, and occasionally melanoma.
Adverse effects
Nausea, vomiting, oral ulcers, myelosuppression, mutagenesis, allergic reactions.

melphalan

Alkeran^® Oncology An oral alkylating anticancer nitrogen mustard agent used to treat ovarian CA and myeloproliferative disease Adverse effects Myelosuppression, mutagenesis

melphalan

A drug used in the treatment of POLYCYTHAEMIA VERA, chronic LEUKAEMIA and MYELOMATOSIS. A brand name is Alkeran.

melphalan

melphalan

melphalan

melphalan

melphalan (L-PAM, L-phenylalanine mustard, L-sarcolysin)

melphalan hydrochloride

FDA Box Warning

Action

Availability

Indications and dosages

Dosage adjustment

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

melphalan

melphalan

melphalan

melphalan

Synonyms for melphalan

noun antineoplastic drug (trade name Alkeran) used to treat multiple myeloma and some other malignancies

Synonyms

Related Words