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DictionarySeedystrophyAdiposogenital Dystrophy
adiposogenital dystrophy[¦ad·ə‚pō·sō′jen·əd·əl ′dis·trə·fē] (medicine) A syndrome involving obesity, retarded gonad development, and sometimes diabetes insipidus resulting from impaired functioning of the pituitary and hypothalamus. Also known as Froehlich's syndrome. Dystrophy, Adiposogenital a disorder associated with impairment of function of the endocrine glands (hypophysis) and diencephalon, characterized by adiposity, retardation of growth, and underdevelopment or atrophy of the gonads and secondary sex characteristics. Adiposogenital dystrophy is seen with lesions (most often tumors, hemorrhages, or infections) in the region of the sella turcica, hypothalamus, or ventriculus tertius cerebri. Under-development of the genitalia is especially manifest during the period of pubescence. Adiposity in adiposogenital dystrophy gives boys an effeminate appearance and gives girls a more mature look. The condition is accompanied by dizziness, headaches, diminished libido and sexual potency, and impairment of vision. Sometimes there are emotional changes, sudden shifts of mood, reduced ability to concentrate on a single activity, and lessened capacity for memorization. Familial predisposition to the disease is possible. The condition may be treated by surgery, X rays, or hormones; if the dystrophy is of infectious origin the treatment should be specific. L. M. GOL’BER adiposogenital dystrophy
adiposogenital dystrophy [ad″ĭ-po-so-jen´ĭ-t'l dis´trah-fe] increased body fat (obesity) accompanied by underdevelopment of the genitalia and altered secondary sex characteristics, caused by damage to certain parts of the hypothalamus, with a decrease in the secretion of gonadotropic hormones from the anterior lobe of the pituitary gland. Treatment depends on the primary cause of the condition, usually a tumor or infection involving the hypothalamus. Called also adiposogenital syndrome and Fröhlich's syndrome.ad·i·po·so·gen·i·tal dys·tro·phya disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Vision loss, behavioral abnormalities, and diabetes insipidus may occur. Fröhlich syndrome is a common synonym for this disorder. Although the original case involved a pituitary tumor, most cases are thought to result from hypothalamic dysfunction in areas regulating appetite and gonadal development. The most common causes are pituitary and hypothalamic neoplasms. Synonym(s): adiposis orchica, adiposogenital degeneration, adiposogenital syndrome, dystrophia adiposogenitalis, Fröhlich syndrome, hypophysial syndrome, hypothalamic obesity with hypogonadism, Launois-Cléret syndromedys·tro·phi·a ad·i·po·so·ge·ni·ta·lis (dis-trō'fē-ă ad-i-pō'sō-jen-i-tā'lis) A disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Visual loss, behavioral abnormalities, and diabetes insipidus may occur. The most common causes are pituitary and hypothalamic neoplasms.
Synonym(s): adiposogenital dystrophy, Fröhlich syndrome, hypophysial syndrome. adiposogenital dystrophy See FROHLICH'S SYNDROME.dys·tro·phi·a ad·i·po·so·ge·ni·ta·lis (dis-trō'fē-ă ad-i-pō'sō-jen-i-tā'lis) Disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys.
Synonym(s): adiposogenital dystrophy, Fröhlich syndrome, hypophysial syndrome. |