释义 |
kringle
krin·gle (krin'gĕl), A structural motif or domain seen in certain proteins in which a fold of large loops is stabilized by disulfide bonds; an important structural feature in blood coagulation factors. [Ger. Kringel, curl] A triple-looped, disulfide-linked protein domain involved in binding membranes, proteins and phospholipids, and in regulating proteolysis; it is a common structural motif present in coagulation-related, fibrinolytic and other plasma proteinases—e.g., tPA, urokinase and apolipoprotein Akrin·gle (kring'gĕl) A structural motif or domain seen in certain proteins in which a fold of large loops is stabilized by disulfide bonds; an important structural feature in blood coagulation factors. [Ger. Kringel, curl]kringle (krĭng′gl) A subunit of plasminogen consisting of 80 amino acids in a loop structure. |