nodular lymphoid hyperplasia

A bone marrow finding variously defined as:
(1) The presence of ≥ 4 normal lymphoid aggregates (average size 0.3 mm) in any low-power (40x) light microscopic field; or
(2) An enlarged (> 0.6 mm) lymphoid nodule.
Nodular lymphoid hyperplasia occurs in up to 60% of bone marrow specimens, at autopsy and, when extreme, mimics a lymphoproliferative process.

Associations
ITP, rheumatoid arthritis, cirrhosis, hyperthyroidism, anaemia (autoimmune, haemolytic, drug-related, iron deficiency, and refractory), macroglobulinaemia, Hodgkin lymphoma, large-cell lymphoma, and cryoglobulinaemia.

DiffDx
CLL, primary small-cell lymphoma, well-differentiated lymphoma.

nodular lymphoid hyperplasia (small intestine)

The presence in younger (< age 30) adults of multiple submucosal lymphoid aggregates with prominent germinal centres, most common in the small intestine, but which also occurs in the stomach and the large intestine. In children, NLH may be nonspecific; in adults it is usually pathological and associated with defects in humoral immunity—e.g., selective IgA deficiency, common variable immune deficiency/ hypogammagolulineamia, HIV infection. It may occur in absence of humoral immune defects in patients with giardiasis.
Clinical findings
Range from mild GI discomfort (in IgA deficiency) to severe malabsorption, chronic diarrhoea, recurrent bacterial infections with sinusitis, bronchitis, bronchiectasis, pneumonia (in CVID). Recurrent infections seen in NLH Campylobacoccidiangardiasis, cryptosporidiosis.

单词	nodular lymphoid hyperplasia
释义	nodular lymphoid hyperplasia nodular lymphoid hyperplasia A bone marrow finding variously defined as: (1) The presence of ≥ 4 normal lymphoid aggregates (average size 0.3 mm) in any low-power (40x) light microscopic field; or (2) An enlarged (> 0.6 mm) lymphoid nodule. Nodular lymphoid hyperplasia occurs in up to 60% of bone marrow specimens, at autopsy and, when extreme, mimics a lymphoproliferative process. Associations ITP, rheumatoid arthritis, cirrhosis, hyperthyroidism, anaemia (autoimmune, haemolytic, drug-related, iron deficiency, and refractory), macroglobulinaemia, Hodgkin lymphoma, large-cell lymphoma, and cryoglobulinaemia. DiffDx CLL, primary small-cell lymphoma, well-differentiated lymphoma. nodular lymphoid hyperplasia (small intestine) The presence in younger (< age 30) adults of multiple submucosal lymphoid aggregates with prominent germinal centres, most common in the small intestine, but which also occurs in the stomach and the large intestine. In children, NLH may be nonspecific; in adults it is usually pathological and associated with defects in humoral immunity—e.g., selective IgA deficiency, common variable immune deficiency/ hypogammagolulineamia, HIV infection. It may occur in absence of humoral immune defects in patients with giardiasis. Clinical findings Range from mild GI discomfort (in IgA deficiency) to severe malabsorption, chronic diarrhoea, recurrent bacterial infections with sinusitis, bronchitis, bronchiectasis, pneumonia (in CVID). Recurrent infections seen in NLH Campylobacoccidiangardiasis, cryptosporidiosis.
随便看	onmss onmt onmun on my account on my agenda on my back on my beam ends on my beam-ends on my behalf on my best behavior on my best behaviour on my bill on my brain on my case on my coattails on my conscience on my deathbed on my door step on my doorstep on my feet on my good behavior on my good behaviour on my guard on my hands on my hands and knees