| 单词 | light chain deposition disease |
| 释义 | light chain deposition diseaselight chain diseaseA nephropathy which presents with nephrotic range proteinuria and rapidly progressive renal failure due to deposition of electron-dense material within tubular and glomerular basement membranes.Clinical findings Nephrotic syndrome, heart failure, arrhythmias, liver disease, anorexia, nausea, weight loss, anaemia, increased creatinine, and neurologic disease; similar clinical findings occur in heavy chain deposition. light chain deposition diseaseBence-Jones myeloma, light chain disease Oncology A paraproteinemia linked to renal amyloidosis, which occurs in 20% of Pts with immunoproliferative disorders; both are characterized by deposits of fibrillar and nonfibrillar monoclonal light chains in various tissues Clinical Rapidly progressive renal failure due to renal tubular blockage by Bence-Jones proteins, nephrotic syndrome, heart failure, arrhythmias, liver disease, neurologic disease; similar clinical findings are associated with heavy chain depositionSee LCDD |
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