| 单词 | nicotinamide adenine dinucleotide | |||
| 释义 | nicotinamide adenine dinucleotidenic·o·tin·a·mide adenine dinucleotideN0098000 (nĭk′ə-tĭn′ə-mīd′, -tē′nə-)NAD
nicotinamide adenine dinucleotidenicotinamide adenine dinucleotideandnicotinamide adenine dinucleotide phosphate:see coenzymecoenzyme, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in ..... Click the link for more information. . Nicotinamide adenine dinucleotide (NAD)An organic coenzyme and one of the most important components of the enzymatic systems concerned with biological oxidation-reduction reactions. It is also known as NAD, diphosphopyridine nucleotide (DPN) coenzyme I, and codehydrogenase I. NAD is found in the tissues of all living organisms. See Coenzyme The nicotinamide, or pyridine, portion of NAD can be reduced chemically or enzymatically with the formation of reduced or hydrogenated NAD (NADH). NAD functions as the immediate oxidizing agent for the oxidation, or dehydrogenation, of various organic compounds in the presence of appropriate dehydrogenases, which are specific apoenzymes, or protein portions of the enzyme. In the dehydrogenase reactions one hydrogen atom is transferred from the substrate to NAD, while another is liberated as hydrogen ion. NAD and its reduced form, NADH, serve to couple oxidative and reductive processes and are constantly regenerated during metabolism. Hence, they serve as catalysts and NAD is referred to as a coenzyme. In some enzymatic reactions a different coenzyme, triphosphopyridine nucleotide is required. Dehydrogenases are generally quite specific with respect to the coenzyme which they can utilize. See Enzyme, Nicotinamide adenine dinucleotide phosphate (NADP) Nicotinamide Adenine Dinucleotide(NAD; also called diphosphopyridine nucleotide, or DPN; obsolete terms, cozymase, coenzyme I, and codehydrogenase I), a coenzyme present in all living cells. NAD is a member of a group of enzymes—the dehydrogenases—that catalyze oxidation-reduction reactions. NAD was discovered in 1904 in yeast juice by the British biochemists A. Harden and W. Young, and its structure was established in 1936 by O. Warburg and H. Euler. The NAD molecule consists of adenine (1), nicotinic acid amide (2), two radicals of the carbohydrate ribose (3), and two phosphate radicals (4). Another very important coenzyme—nicotinamide adenine dinucleotide phosphate, or NADP—contains in its molecule still another phosphate radical bound to the 21-carbon of the ribose radical. The two coenzymes have the following structure:
In many oxidation-reduction reactions, NAD or NADP binds a proton and two electrons transferred from an oxidizable substrate to an oxidized coenzyme. In the reverse reaction, hydrogen is transferred from the reduced coenzyme to the substrate. Meanwhile, hydrogen is uncoupled and attached to the 4-carbon of the nicotinic acid amide:
Both NAD and NADP participate in carbohydrate, protein, and fat metabolism. S. A. OSTROUMOV nicotinamide adenine dinucleotide[‚nik·ə′tin·ə‚mīd ′ad·ən‚ēn dī′nü·klē·ə‚tīd]nicotinamide adenine dinucleotidenic·o·tin·a·mide ad·e·nine di·nu·cle·o·tide (NAD, NAD+, NADH),(nik'ō-tin'ă-mīd ad'ĕ-nīn dī-nū'klē-ō-tīd),nicotinamide adenine dinucleotide(nĭk′ə-tĭn′ə-mīd′, -tē′nə-)nic·o·tin·a·mide ad·e·nine di·nu·cle·o·tide(NAD) (nik'ō-tin'ă-mīd ad'ĕ-nēn dī-nū'klē-ō-tīd)See also: entries under NAD and NADP Synonym(s): diphosphopyridine nucleotide. See NADH nicotinamide adenine dinucleotide
Synonyms for nicotinamide adenine dinucleotide
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