单词 | benzimidazole |
释义 | benzimidazoleben·zim·id·az·oleB0194400 (bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)benzimidazole(ˌbɛnzɪˈmaɪdəˌzəʊl)benzimidazolebenzimidazole[‚ben·zə′mid·ə‚zȯl]benzimidazolebenz·im·id·a·zole(benz-im-id-ā'zōl),benzimidazole(bĕn′zə-mĭ-dăz′ōl′, -mĭd′ə-zōl′)benzimidazoleA family of broad-spectrum antiparasitics (abendazole, mebendazole, thiabendazole) active against nematodes (roundworms, ascariasis, enterobius, hookworm infection, strongyloidiasis, trichuriasis), cestodes (flatworms, cysticercosis, echinococcosis) and protozoa (giardiasis, microsporidiosis); benzimidazole acts by binding free beta-tubulin, inhibiting its polymerisation and the microtubule-dependent uptake of glucose.Adverse effects Abdominal pain, nausea, vomiting, alopecia, increased aminotransferases, neutropenia. |
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