释义 |
mismatch repair gene mismatch repair gene Any of a number of genes (e.g., MLH1, PMS1, MSH2, etc.) which encode an enzyme that scans newly replicated DNA for errors and repairs mismatched bases in the DNA. Defects in mismatch repair genes result in replication errors and genetic instability. Germ-line mutations are associated with hereditary cancer syndromes—e.g., hereditary nonpolyposis colorectal cancer. |