M40403
M40403
A small superoxide dismutase mimetic that removes superoxides, converting toxic free radicals into O2 and H2O2, which are decomposed by catalase. It is being developed as a co-therapy with IL-2 for managing skin and kidney cancers, and has favourable therapeutic effects in animal models of acute myocardial infarction, stroke, inflammatory bowel disease, rheumatoid arthritis, diabetic microangiopathies and septic shock.Pros
Lower molecular weight than SOD; penetrates cells and membranes easily; more stable; longer half-life; does not trigger an immune response.