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lipoic acid
li·po·ic acid L5202400 (lĭ-pō′ĭk)n. An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.
[lip(o)- + -oic.]lipoic acid n (Biochemistry) biochem a sulphur-containing fatty acid, regarded as an element of the vitamin B complex, minute amounts of which are required for carbohydrate metabolism See lipoic acid
lipoic acid
lipoic acid: see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
..... Click the link for more information. .Lipoic Acid 6,8-epi-dithio-octanoic acid, a widespread naturally occurring coenzyme, related to enzymes of the class of oxidoreductases. It exists in the form of crystals with melting point 59°-60°C and was first isolated from bull’s liver in 1941 (30 mg of lipoic acid was obtained from 10 tons of liver). Lipoic acid participates in the transfer of acyl groups (acid radicals) and in biological oxidation reactions (for example, oxidative decarboxylation of pyruvic and ketoglutaric acids for conversion into acetyl-CoA and succinyl-CoA, respectively, with liberation of carbon dioxide). The oxidized form of lipoic acid is transformed into a reduced form, which is then reconverted into the oxidized form upon action of a specific enzyme: 
Lipoic acid is the growth factor (vitamin) in certain microorganisms; it exists in composite protein form in the cells of plant and animal tissues. lipoic acid[lī′pō·ik ′as·əd] (biochemistry) C8H14O2S2 A compound which participates in the enzymatic oxidative decarboxylation of α-keto acids in a stage between thiamine pyrophosphate and coenzyme A. lipoic acid
li·po·ic ac·id (li-pō'ik as'id), A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes. Synonym(s): acetate replacement factor, ovoprotogen, protogen, protogen A, pyruvate oxidation factor, thioctic acidlipoic acid (lĭ-pō′ĭk)n. An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.ThesaurusSeecoenzyme |