lipophagic granuloma


granuloma

 [gran″u-lo´mah] (pl. granulomas, granulo´mata) an imprecise term applied to (1) any small nodular, delimited aggregation of mononuclear inflammatory cells, or (2) a similar collection of modified macrophages resembling epithelial cells, usually surrounded by a rim of lymphocytes, often with multinucleated giant cells. Some granulomas contain eosinophils and plasma cells, and fibrosis is commonly seen around the lesion. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents.apical granuloma modified granulation tissue containing elements of chronic inflammation located adjacent to the root apex of a tooth with infected necrotic pulp.actinic granuloma an annular lesion seen on skin chronically exposed to the sun, with a raised border and a center that appears normal but is actually elastotic" >elastotic.benign granuloma of thyroid chronic inflammation of the thyroid gland, converting it into a bulky tumor that later becomes extremely hard.coccidioidal granuloma the secondary stage of coccidioidomycosis" >coccidioidomycosis.dental granuloma one usually surrounded by a fibrous sac continuous with the periodontal ligament and attached to the root apex of a tooth.eosinophilic granuloma 1. Langerhans cell histiocytosis.2. a disorder similar to eosinophilic gastroenteritis, characterized by localized nodular or pedunculated lesions of the submucosa and muscle walls, especially of the pyloric area of the stomach, caused by infiltration of eosinophils, but without peripheral eosinophilia and allergic symptoms.granuloma fissura´tum a firm, whitish, fissured, fibrotic granuloma of the gum and buccal mucosa, occurring on an edentulous alveolar ridge and between the ridge and the cheek.foreign-body granuloma a localized histiocytic reaction to a foreign body in the tissue.giant cell reparative granuloma, central a lesion of the jaws composed of a spindle cell stroma punctuated by multinucleate giant cells, considered by most to be a central lesion of the bone of the jaws, presenting an inflammatory reaction to injury or hemorrhage. Some, however, consider it to be a giant cell tumor occurring in both benign and malignant forms, and others consider it to be a form of osteogenic sarcoma, varying in degree of malignancy.granuloma inguina´le a granulomatous disease that is associated with uncleanliness and is caused by the microorganism Calymmatobacterium granulomatis (sometimes called a Donovan body). Called also granuloma venereum. Although granuloma inguinale is often considered to be a venereal disease, research does not support the hypothesis that it is transmitted by sexual contact. It is possible that natural resistance to the disease is high, so that only a few of the persons exposed are affected. About 10 days to 3 months may elapse after exposure until appearance of the first symptoms, usually small painless ulcers that bleed easily. Swelling in the groin may then follow. A new ulcer or ulcers may appear as the old one heals, so that granuloma inguinale may eventually cover the reproductive organs, buttocks, and lower abdomen, with extensive sores and a foul odor. As persons who have the disease seem to develop little immunity to it, granuloma inguinale can be present for many years.
Treatment of the disease may be with streptomycin. tetracyclines, or lincomycin. There is no known preventive for granuloma inguinale, although it is rare where sanitary living conditions prevail. The drainage from lesions may be infectious and handwashing and basic cleanliness are required. The Centers for Disease Control and Prevention recommends standard precautions.lipoid granuloma xanthoma.lipophagic granuloma a granuloma attended by the loss of subcutaneous fat.Majocchi's granuloma trichophytic granuloma.midline granuloma a rare disease of unknown etiology, characterized by granulomatous lesions of the nasal mucosa, sinuses, palate, and pharynx. Massive, progressive, erosive lesions that destroy the involved soft tissue, cartilage, and bone and sometimes extend to the brain are typical. Untreated cases are fatal (lethal midline granuloma).paracoccidioidal granuloma paracoccidioidomycosis.peripheral giant cell reparative granuloma giant cell epulis.pyogenic granuloma a benign, solitary nodule resembling granulation tissue, found anywhere on the body, commonly intraorally, usually at the site of trauma as a response of the tissues to a nonspecific infection.sarcoid granuloma the granuloma seen with sarcoidosis, consisting of multinucleated giant cells surrounded by macrophages and epithelioid cells derived from macrophages.swimming pool granuloma a chronic granulomatous bacterial infection caused by contamination of an abrasion sustained in a swimming pool by Mycobacterium marinum, which histologically and clinically resembles tuberculosis. It tends to heal spontaneously within a few months to 2 years.granuloma telangiecta´ticum a form characterized by numerous dilated blood vessels.trichophytic granuloma a form of tinea corporis" >tinea corporis seen mainly on the lower legs, due to infection of hairs by the fungus Trichophyton; characteristics include raised, circumscribed, boggy granulomas that are disseminated or arranged in chains. Lesions are slowly absorbed or undergo necrosis, leaving depressed scars. Called also Majocchi's granuloma.granuloma tro´picum yaws.granuloma vene´reum granuloma inguinale.

lip·o·pha·gic gran·u·lo·ma

a lesion formed as a result of the inflammatory reaction provoked by foci of necrosis in subcutaneous fat, as in certain types of traumatic injury; the central focus of necrotic material is surrounded by an irregular zone of numerous macrophages, many of which become laden with tiny globules of lipid.

lipophagic granuloma

A granuloma in which the macrophages have phagocytosed the surrounding fat cells.See also: granuloma