单词 | mitf | ||||||||||
释义 | MITFMITFMicrophthalmia transcription factor. A helix-loop-helix leucine zipper-type transcription factor encoded by MITF on chromosome 3p14.2-p14.1, which is involved in melanocyte and osteoclast development. MITF controls the DNA damage response, and plays a critical role in melanoma proliferation; its inhibition is associated with G0-G1 growth arrest, and lineage-specific senescence in melanomas.MITF
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