| 释义 |
osteopetrosis
osteopetrosis (ˌɒstɪəʊpɛˈtrəʊsɪs) n (Medicine) a disorder characterized by bone thickeningThesaurus| Noun | 1. |  osteopetrosis - an inherited disorder characterized by an increase in bone density; in severe forms the bone marrow cavity may be obliteratedAlbers-Schonberg disease, marble bones diseasecongenital disease, genetic abnormality, genetic defect, genetic disease, genetic disorder, hereditary condition, hereditary disease, inherited disease, inherited disorder - a disease or disorder that is inherited genetically |
Translationsosteopetrosis
osteopetrosis[¦äs·tē·ō·pə′rō·səs] (medicine) A rare developmental error of unknown cause but of familial tendency, characterized chiefly by excessive radiographic density of most or all of the bones. Also known as marble bone disease. osteopetrosis
osteopetrosis [os″te-o-pĕ-tro´sis] a rare hereditary, congenital condition in which there are bandlike areas of condensed bone at the epiphyseal lines of long bones and condensation of the edges of smaller bones. Fractures occur frequently and deformities of the head, chest, or spine develop. There is no treatment and the prognosis is unfavorable. There may be obliteration of the marrow spaces, causing anemia. Called also Albers-Schönberg disease and marble bones.os·te·o·pe·tro·sis (os'tē-ō-pe-trō'sis), [MIM*166600] Excessive formation of dense trabecular bone and calcified cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness; autosomal dominant inheritance. There are also autosomal recessive forms, which may be mild [MIM*259710], severe [MIM*259700], or lethal [MIM*259720], and sometimes involve a renal tubular defect [MIM*259730]. A milder, autosomal dominant form has onset in childhood and no neurologic sequelae. Synonym(s): Albers-Schönberg disease, marble bone disease, marble bones [osteo- + G. petra, stone, + -osis, condition] osteopetrosis Albers-Schoenberg disease, marble bone disease Pediatric endocrinology A heterogeneous group of rare AD and cortical and trabecular osteosclerotic disorders, characterized by ↓ osteoclastic activity and ↓ bone resorption, with accumulation of sclerotic bone, compromising marrow space Management IFN-gamma-1b, BMT, high-dose calcitriolos·te·o·pe·tro·sis (os'tē-ō-pĕ-trō'sis) Excessive formation of dense trabecular bone and calcified cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia, with myeloid metaplasia and hepatosplenomegaly, beginning in infancy and with progressive deafness and blindness.
Synonym(s): Albers-Schönberg disease. [osteo- + G. petra, stone, + -osis, condition]osteopetrosis A group of hereditary bone disorders featuring increased density (‘marble bones’) but increased fragility (‘osteosclerosis fragilis’). In some cases excessive bone growth can cause pressure effects on nerves passing through bony canals. The condition is due to a defect of bone resorption by OSTEOCLASTS so that osteoblastic bone synthesis proceeds unchecked. It can sometimes be treated by bone marrow transfusion to provide normal osteoclasts. Also known as Albers-Schonberg disease after Heinrich Ernst Albers Schönberg (1865–1921) who was professor of radiology at Hamburg.Albers-Schönberg, Heinrich Ernst, German radiologist, 1865-1921. Albers-Schönberg disease - excessive formation of dense trabecular bone and calcified cartilage. Synonym(s): osteopetrosisos·te·o·pe·tro·sis (os'tē-ō-pĕ-trō'sis) [MIM*166600] Excessive formation of dense trabecular bone and calcified cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy. [osteo- + G. petra, stone, + -osis, condition]See OPTA
See OPTAosteopetrosis
Related to osteopetrosis: osteogenesis imperfectaSynonyms for osteopetrosisnoun an inherited disorder characterized by an increase in bone densitySynonyms- Albers-Schonberg disease
- marble bones disease
Related Words- congenital disease
- genetic abnormality
- genetic defect
- genetic disease
- genetic disorder
- hereditary condition
- hereditary disease
- inherited disease
- inherited disorder
|