BAG6

A gene on chromosome 6p21.3 that encodes a chaperone which plays a key role in various processes, such as DNA damage-induced apoptosis, insertion of tail-anchored (TA) membrane proteins in the endoplasmic reticulum membrane and regulation of chromatin. BAG6/BAT3 acts by facilitating tail-anchored (TA) membrane proteins captured by ASNA1/TRC40: it is recruited to ribosomes synthesising membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. BAG6 is required:
• During spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2; and
• For selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome; it may play a role in immuno-proteasomes, generating antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response.

单词	bag6
释义	DictionarySeeG3 BAG6 BAG6 A gene on chromosome 6p21.3 that encodes a chaperone which plays a key role in various processes, such as DNA damage-induced apoptosis, insertion of tail-anchored (TA) membrane proteins in the endoplasmic reticulum membrane and regulation of chromatin. BAG6/BAT3 acts by facilitating tail-anchored (TA) membrane proteins captured by ASNA1/TRC40: it is recruited to ribosomes synthesising membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. BAG6 is required: • During spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2; and • For selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome; it may play a role in immuno-proteasomes, generating antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response.
随便看	finite element method of lines finite element method - surface integral equation finite element method with integral equation boundary condition finite element model finite element model builder finite element model for groundwater finite element modeling and postprocessing finite element modeling continuous improvement finite element modeling group finite element model updating finite element ocean model finite element of water finite-element polycrystal model finite element primitive equation finite element problem finite element program generator finite element subsurface flow system finite-element surface water modeling system finite-element time domain finite element tree crown hydrodynamics finite element visual analysis finite energy sum rules finite ergodic markov source finite extension finite field