orthostatic intolerance

A condition (OMIM:604715) characterised by lightheadedness, fatigue, altered mentation, syncope and tachycardia upon assuming an upright position, and markedly elevated serum norepinephrine.
Molecular pathology
Defects in SLC6A2, which encodes a member of the sodium:neurotransmitter symporter that regulates norepinephrine homeostasis, are a cause of orthostatic intolerance.

or·tho·stat·ic in·tol·er·ance

(ōr'thō-stat'ik in-tol'ĕr-ăns) Decreased venous return in the upright position typically experienced by astronauts after returning to an environment subject to gravity.

orthostatic intolerance

Loss of consciousness, near fainting, or light-headedness occurring when a person stands up from a seated or resting position. It is caused by insufficient blood flow to the brain, typically brought on by inability to raise blood pressure during changes in posture.

单词	orthostatic intolerance
释义	EncyclopediaSeeNCD orthostatic intolerance orthostatic intolerance A condition (OMIM:604715) characterised by lightheadedness, fatigue, altered mentation, syncope and tachycardia upon assuming an upright position, and markedly elevated serum norepinephrine. Molecular pathology Defects in SLC6A2, which encodes a member of the sodium:neurotransmitter symporter that regulates norepinephrine homeostasis, are a cause of orthostatic intolerance. or·tho·stat·ic in·tol·er·ance (ōr'thō-stat'ik in-tol'ĕr-ăns) Decreased venous return in the upright position typically experienced by astronauts after returning to an environment subject to gravity. orthostatic intolerance Loss of consciousness, near fainting, or light-headedness occurring when a person stands up from a seated or resting position. It is caused by insufficient blood flow to the brain, typically brought on by inability to raise blood pressure during changes in posture.
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