mibefradil


mibefradil

A calcium-channel blocker that vasodilates without reflex tachycardia, which was used to manage hypertension or chronic stable angina. It was pulled from the market due to its inhibition of the liver metabolism of certain drugs (e.g., antihistamines) and statins, and increased mortality in patients with congestive heart failure.

mibefradil

Posicor® Cardiology A CCB that vasodilates without reflex tachycardia, used to manage HTN and angina pectoris; it was pulled from the market as it inhibits liver metabolism of certain drugs–eg, antihistamine, Histamal, and statin cholesterol-lowering agents. See Calcium channel blocker.