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Michaelis-Menten equation
Michaelis-Menten equation[‚mik·ä¦ā·ləs ′men·tən i‚kwā·zhən] (biochemistry) A mathematical equation expressing the hyperbolic relationship between the initial velocity, Vo , and the substrate concentration, [S ], in a number of enzyme-catalyzed reactions such that Vo = Vmax[S ]/ Km + [S ], where Vmaxis the maximum velocity and Km is the Michaelis constant. Michaelis-Menten equation
Mi·chae·lis-Men·ten e·qua·tion (mi-kā'lis men'tĕn), an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration; v = Vmax [S]/(Km + [S]), where v is the initial velocity of the reaction, Vmax is the maximum velocity, [S] is the initial substrate concentration, and Km is the Michaelis constant. Similar equations can be derived for conditions in which the product is present and for multisubstrate enzymes. Synonym(s): Henri-Michaelis-Menten equation [Leonor michaelis, Maud L. Menten] Michaelis-Menten equation An equation for evaluating enzyme kinetics in a system: v = VS/Km + S, where v = Initial velocity of reaction; V = Maximum (or limiting) velocity; S = Substrate concentration; and Km = Michaelis constant.
The MME assumes that rapid equilibrium is reached among the enzyme, its substrate and the enzyme-substrate complex, and that the initial velocity of the reaction is proportional to the concentration of the enzyme-substrate complex.Menten, Maud Leonora, Canadian pathologist in U.S., 1879-1960. Michaelis-Menten constant - Synonym(s): Michaelis constantMichaelis-Menten equation - see under MichaelisMichaelis-Menten hypothesis - see under MichaelisVictor-Michaelis-Menten equation - Synonym(s): Michaelis-Menten equation
Michaelis, Leonor, German-U.S. chemist and physician, 1875-1949. Michaelis bufferMichaelis constant - the true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction. Synonym(s): Michaelis-Menten constantMichaelis-Gutmann body - a rounded homogenous body containing calcium and iron found within macrophages in the bladder wall in malacoplakia.Michaelis-Menten constant - Synonym(s): Michaelis constantMichaelis-Menten equation - an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration. Synonym(s): Victor-Michaelis-Menten equationMichaelis-Menten hypothesis - that a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (Brown hypothesis), the latter rate determining the overall rate of substrate-product conversion.Victor-Michaelis-Menten equation - Synonym(s): Michaelis-Menten equation |