MMP9
MMP9
A gene on chromosome 20q12-q13 that encodes matrix metalloproteinase 9, which degrades collagens IV and V, gelatins I and V, and fibronectin. It is thought to play a key role in local proteolysis of the extracellular matrix and in leukocyte migration, and may play a role in osteoclastic resorption of bone.Molecular pathology
Defects in MMP9 increase susceptibility to intervertebral disc disease and lumbar disc herniation; MMP9 defects cause metaphyseal anadysplasia type 2.