myeloproliferative disorders


myeloproliferative

 [mi″ĕ-lo-pro-lif´er-ah″tiv] pertaining to or characterized by abnormal proliferation of bone marrow constituents.myeloproliferative disorders a group of usually neoplastic diseases, which may be related histogenetically by a common multipotential stem cell; it includes among others leukemia" >acute myelogenous leukemia, leukemia" >chronic granulocytic leukemia, acute and leukemias" >chronic myelomonocytic leukemias, and polycythemia vera. An interrelationship with the lymphoproliferative disorders is thought to exist.

myeloproliferative disorders

A group of diseases featuring excessive production of blood cells by bone marrow precursors. The group includes POLYCYTHAEMIA VERA, chronic myelogenous LEUKAEMIA, platelet over-production (essential THROMBOCYTHAEMIA) and idiopathic MYELOFIBROSIS. A common feature is clonal haematopoiesis probably involving the haematopoietic stem cell. A high proportion of patients with these disorders have a mutation of the Janus kinase 2 (JAK2) gene on the short arm of chromosome 9.