necroptosis

A more recent term for regulated cell necrosis, which is carried out by so-called death receptors—e.g., tumour necrosis factor receptor 1, which requires receptor-interacting protein kinase 1 (encoded by RIPK1) and receptor-interacting protein kinase 3 (encoded by RIPK3). Necroptosis requires the active disintegration of mitochondrial, lysosomal and plasma membranes, and it is pathogenetically linked to ischaemic injury, neurodegeneration and viral infection, making the process an attractive therapeutic target in the future. It contrasts to apoptosis (formerly regarded as the only form of programmed cell death to be carried out during development, homeostasis and disease) and to necrosis (which is regarded as an unregulated and uncontrollable process).

单词	necroptosis
释义	necroptosis necroptosis A more recent term for regulated cell necrosis, which is carried out by so-called death receptors—e.g., tumour necrosis factor receptor 1, which requires receptor-interacting protein kinase 1 (encoded by RIPK1) and receptor-interacting protein kinase 3 (encoded by RIPK3). Necroptosis requires the active disintegration of mitochondrial, lysosomal and plasma membranes, and it is pathogenetically linked to ischaemic injury, neurodegeneration and viral infection, making the process an attractive therapeutic target in the future. It contrasts to apoptosis (formerly regarded as the only form of programmed cell death to be carried out during development, homeostasis and disease) and to necrosis (which is regarded as an unregulated and uncontrollable process).
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