nitazoxanide

Alinia

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism

Availability

Oral suspension: 100 mg/5 ml

Tablets: 500 mg

Indications and dosages

➣ Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 4 to 11: 200 mg (10 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 1 to 3: 100 mg (5 ml suspension) P.O. every 12 hours with food for 3 days

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension)

• concurrent use of warfarin or other highly plasma protein-bound drugs

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 11 (tablets) or age 1 (suspension).

Administration

• Give with food.

• Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11.

• Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, abdominal pain

Interactions

Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy

Patient monitoring

• Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction.

• Monitor blood glucose levels in diabetic patients taking oral suspension.

Patient teaching

• Instruct patient to take drug with food.

• Inform diabetic patient that oral suspension contains sucrose.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

nitazoxanide

A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C.

nitazoxanide

A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.

单词	nitazoxanide
释义	nitazoxanide nitazoxanide Alinia *Pharmacologic class:* Antiprotozoal *Therapeutic class:* Anti-infective *Pregnancy risk category B* Action Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism Availability Oral suspension: 100 mg/5 ml Tablets: 500 mg Indications and dosages ➣ Diarrhea caused by Giardia lamblia or Cryptosporidium parvum Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P.O. every 12 hours with food for 3 days Children ages 4 to 11: 200 mg (10 ml suspension) P.O. every 12 hours with food for 3 days Children ages 1 to 3: 100 mg (5 ml suspension) P.O. every 12 hours with food for 3 days Contraindications • Hypersensitivity to drug or its components Precautions Use cautiously in: • renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension) • concurrent use of warfarin or other highly plasma protein-bound drugs • elderly patients • pregnant or breastfeeding patients • children younger than age 11 (tablets) or age 1 (suspension). Administration • Give with food. • Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11. • Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion. Adverse reactions CNS: headache GI: nausea, vomiting, diarrhea, abdominal pain Interactions Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy Patient monitoring • Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction. • Monitor blood glucose levels in diabetic patients taking oral suspension. Patient teaching • Instruct patient to take drug with food. • Inform diabetic patient that oral suspension contains sucrose. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above. nitazoxanide A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C. nitazoxanide A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.
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