单词 | myositis ossificans |
释义 | myositis ossificansmyositis ossificans[‚mī·ə′sīd·əs ä′sif·ə‚kanz]myositis ossificansmyositis[mi″o-si´tis]my·o·si·tis os·sif·'i·cansmyositis ossificansA term that is slowly being retired from the medical literature, largely in favour of heterotopic ossification, given that(1) inflammation is not a necessary precursor for heterotopic ossification; and (2) the ossification doesn’t always occur in muscle, but may occur in fascia, tendons, and other mesenchymal soft tissues. Clinical forms, myositis ossificans • Localised: linked to trauma. • Generalised: now known as fibrodysplasia ossificans progressiva, which is often due to spontaneous mutation, resulting in autosomal dominant pattern of inheritance in the proband’s progeny. myositis ossificansBone formed within muscle; localized MO is 2º to trauma resulting from a blow or muscle tearing; generalized MO is AD, often accompanied by aplasia of the thumb, great toe, or rarely other digits, in which the first 'tumor' occurs in the paravertebral or cervical region, followed by multiple ossifying tumors, forming calcifying bridges across muscles and joints resulting in massive rigidity and the Pt is turned into 'stone'. See Zoning phenomenon.het·er·o·top·ic os·si·fi·ca·tion(het'ĕr-ō-top'ik os'i-fi-kā'shŭn)Synonym(s): myositis ossificans. myositis ossificansA rare, usually familial, inflammatory disease of muscle in which CALCIFICATION occurs followed by the formation of bony tissue within the affected muscles. |
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