| 单词 | makorin ring finger protein 1 |
| 释义 | makorin ring finger protein 1makorin ring finger protein 1An E3 ubiquitin ligase encoded by MKRN1 on chromosome 7q34, which catalyses the covalent attachment of ubiquitin moieties onto substrate proteins FILIP1, p53/TP53, CDKN1A and TERT. Makorin ring finger protein 1 keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress. It downregulates telomerase and up- and downregulates RNA polymerase II-dependent transcription. |
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