rimantadine hydrochloride

Flumadine

Pharmacologic class: Miscellaneous and anticholinergic-like agent

Therapeutic class: Antiviral

Pregnancy risk category C

Action

Prevents nucleic acid uncoating during viral cell replication, preventing penetration in host. Also causes dopamine release from neurons.

Availability

Syrup: 50 mg/5 ml

Tablets: 100 mg

Indications and dosages

➣ Treatment of influenza type A

Adults: 100 mg P.O. b.i.d.

➣ Prophylaxis of influenza type A

Adults and children older than age 10: 100 mg P.O. b.i.d.

Children younger than age 10: 5 mg/kg P.O. daily. Maximum dosage is 150 mg daily.

Dosage adjustment

• Renal or hepatic disease

• Seizure disorders

• Elderly patients

Off-label uses

• Parkinson's disease

Contraindications

• Hypersensitivity to drug or amantadine

Precautions

Use cautiously in:

• history of seizures or renal or hepatic disease

• pregnant or breastfeeding patients

• children younger than age 1.

Administration

• Give several hours before bedtime.

• Start therapy within 48 hours of symptom onset and continue for at least 1 week.

Adverse reactions

CNS: headache, dizziness, fatigue, depression, insomnia, poor concentration, asthenia, nervousness

CV: hypotension

EENT: tinnitus

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth, anorexia

Respiratory: dyspnea

Skin: rash

Interactions

Drug-drug. Acetaminophen, aspirin: decreased rimantadine peak blood level

Cimetidine: increased rimantadine blood level

Patient monitoring

• Assess patient's flu symptoms. Notify prescriber if symptoms don't improve within 2 to 3 days.

• Monitor vital signs; watch for hypotension.

• Closely monitor nutritional status and hydration.

Patient teaching

• Advise patient to take several hours before bedtime.

• If patient's taking syrup, tell him to use specially marked oral syringe or measuring device to ensure accurate dose.

• Instruct patient to contact prescriber if symptoms don't improve within 2 to 3 days.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, motor function, and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

rimantadine hydrochloride

(rĕ-măn-tĕ-dēn) An antiviral drug given orally to treat influenza A.

单词	rimantadine hydrochloride
释义	DictionarySeerimantadine rimantadine hydrochloride rimantadine hydrochloride Flumadine *Pharmacologic class:* Miscellaneous and anticholinergic-like agent *Therapeutic class:* Antiviral *Pregnancy risk category C* Action Prevents nucleic acid uncoating during viral cell replication, preventing penetration in host. Also causes dopamine release from neurons. Availability Syrup: 50 mg/5 ml Tablets: 100 mg Indications and dosages ➣ Treatment of influenza type A Adults: 100 mg P.O. b.i.d. ➣ Prophylaxis of influenza type A Adults and children older than age 10: 100 mg P.O. b.i.d. Children younger than age 10: 5 mg/kg P.O. daily. Maximum dosage is 150 mg daily. Dosage adjustment • Renal or hepatic disease • Seizure disorders • Elderly patients Off-label uses • Parkinson's disease Contraindications • Hypersensitivity to drug or amantadine Precautions Use cautiously in: • history of seizures or renal or hepatic disease • pregnant or breastfeeding patients • children younger than age 1. Administration • Give several hours before bedtime. • Start therapy within 48 hours of symptom onset and continue for at least 1 week. Adverse reactions CNS: headache, dizziness, fatigue, depression, insomnia, poor concentration, asthenia, nervousness CV: hypotension EENT: tinnitus GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, dry mouth, anorexia Respiratory: dyspnea Skin: rash Interactions Drug-drug. Acetaminophen, aspirin: decreased rimantadine peak blood level Cimetidine: increased rimantadine blood level Patient monitoring • Assess patient's flu symptoms. Notify prescriber if symptoms don't improve within 2 to 3 days. • Monitor vital signs; watch for hypotension. • Closely monitor nutritional status and hydration. Patient teaching • Advise patient to take several hours before bedtime. • If patient's taking syrup, tell him to use specially marked oral syringe or measuring device to ensure accurate dose. • Instruct patient to contact prescriber if symptoms don't improve within 2 to 3 days. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, motor function, and alertness. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above. rimantadine hydrochloride (rĕ-măn-tĕ-dēn) An antiviral drug given orally to treat influenza A.
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