systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.

systemic inflammatory response syndrome

clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count.

systemic inflammatory response syndrome

A term that 'was developed to imply a clinical response arising from a nonspecific insult and includes two or more of the following. See Sepsis, Septic shock, Severe sepsis. Systemic inflammatory responses Temperature < 36ºC or > 38ºC Heart rate > 90 beats/min Respiratory rate pCO₂ < 32 mm Hg or > 20 breaths/min WBC count < 4 x 109 or > 12 x 109 or , or the presence of > 0.10 immature neutrophils

systemic inflammatory response syndrome

SIRS

Any severe illness characterized by a heart rate > 90 beats per min, respirations exceeding 20 breaths per minute, a PaCO2 of less than 32 mm Hg, and a white blood count greater than 12,000 cells/mL or less than 4000 cells/mL (or the presence of more than 10 percent immature (band) white blood cells. SIRS can begin with any serious illness or injury involving inflammation but is most often associated with systemic infection (sepsis) caused by gram-negative bacteria. See: sepsis; septic shock

Etiology

Lipopolysaccharide endotoxins released by gram-negative and gram-positive bacteria bind with lymphocytes and endothelial cells, stimulating a cascade of cytokine release, which produces systemic inflammation of blood vessels, tissues, and organs. Shock develops when cytokines cause vasodilation and increased vascular permeability; SIRS is one of the main causes of multiple organ dysfunction syndrome.

Treatment

Treatment for SIRS is focused on treating the primary cause. Multiple antibiotic therapy is required in sepsis. Supportive measures include the use of intravenous fluids and pressors, to support blood pressure, and intensive monitoring and optimization of oxygenation, ventilation, blood pressure, cardiac rhythms, serum electrolytes, and renal function.

单词	systemic inflammatory response syndrome
释义	DictionarySeeor systemic inflammatory response syndrome systemic inflammatory response syndrome [si¦stem·ik in‚flam·ə‚tȯr·ē ri′späns ‚sin‚drōm] (medicine) The spectrum of elicited pathophysiologic changes (including blood clotting and changes in metabolism, heart rate, and respiration) resulting from excess production of inflammatory mediators (for example, histamines and leukotrienes), which orchestrate the process of inflammation through various processes. systemic inflammatory response syndrome systemic inflammatory response syndrome clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count. systemic inflammatory response syndrome clinical state consisting of two or more coexisting conditions: fever or hypothermia, tachycardia, tachypnea, and an abnormally high leukocyte count. systemic inflammatory response syndrome A term that 'was developed to imply a clinical response arising from a nonspecific insult and includes two or more of the following. See Sepsis, Septic shock, Severe sepsis. Systemic inflammatory responses Temperature < 36ºC or > 38ºC Heart rate > 90 beats/min Respiratory rate pCO₂ < 32 mm Hg or > 20 breaths/min WBC count < 4 x 109 or > 12 x 109 or , or the presence of > 0.10 immature neutrophils systemic inflammatory response syndrome , SIRS Any severe illness characterized by a heart rate > 90 beats per min, respirations exceeding 20 breaths per minute, a PaCO2 of less than 32 mm Hg, and a white blood count greater than 12,000 cells/mL or less than 4000 cells/mL (or the presence of more than 10 percent immature (band) white blood cells. SIRS can begin with any serious illness or injury involving inflammation but is most often associated with systemic infection (sepsis) caused by gram-negative bacteria. See: sepsis; septic shock Etiology Lipopolysaccharide endotoxins released by gram-negative and gram-positive bacteria bind with lymphocytes and endothelial cells, stimulating a cascade of cytokine release, which produces systemic inflammation of blood vessels, tissues, and organs. Shock develops when cytokines cause vasodilation and increased vascular permeability; SIRS is one of the main causes of multiple organ dysfunction syndrome. Treatment Treatment for SIRS is focused on treating the primary cause. Multiple antibiotic therapy is required in sepsis. Supportive measures include the use of intravenous fluids and pressors, to support blood pressure, and intensive monitoring and optimization of oxygenation, ventilation, blood pressure, cardiac rhythms, serum electrolytes, and renal function. LegalSeeOrFinancialSeeORSee SIRS See SIRSThesaurusSeeheart rate
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