| Acronym | Definition |
|---|
| SPK➣Speaker |
| SPK➣Stiftung Preussischer Kulturbesitz (German: Prussian Cultural Heritage Foundation) |
| SPK➣Spokane (Washington) |
| SPK➣Sistem Pengurusan Kualiti (Malay: Quality Management System) |
| SPK➣Slipknot (band) |
| SPK➣Storage Protection Key |
| SPK➣Software Package |
| SPK➣Spice Toolkit |
| SPK➣Single Pack |
| SPK➣Sermaye Piyasasi Kurulu |
| SPK➣Summer Program for Kids (New York University) |
| SPK➣Salt, Pepper, Ketchup (condiments) |
| SPK➣Synthetic Paraffinic Kerosene (fuel) |
| SPK➣Simultaneous Pancreas-Kidney Transplantation |
| SPK➣Secret Provision for Kira (manga) |
| SPK➣Sour Patch Kids (candy) |
| SPK➣Some People's Kids |
| SPK➣Sozialistisches Patienten Kollektiv |
| SPK➣Soda Pop Krew (skateboarding; Salt Lake City, UT) |
| SPK➣System for Population Kinetics |
| SPK➣System Protection Kit |
| SPK➣Special Provision for Kira (anime) |
| SPK➣Single Point Keying |
| SPK➣South Pacific Division-Sacramento District (USACE) |
| SPK➣Spacecraft and Planet Kernel (US NASA) |
| SPK➣Superficial Punctate Keratitis/Keratopathy |
| SPK➣Surgical Penis Kilinik (band) |
| SPK➣Single Point Kill |
| SPK➣Swenson, Perer & Kontos (law firm; Pittsburgh, PA) |
| SPK➣Summit Point Kart (motorsports park; West Virginia) |
| SPK➣Spacecraft and Target Ephemeris Kernel |