| Acronym | Definition |
|---|
| R2➣Region 2 (DVD region releases) |
| R2➣Residential (zoning) |
| R2➣Resistance 2 (video game) |
| R2➣Radio 2 |
| R2➣Rapid Response |
| R2➣Removed and Replaced |
| R2➣Reporting Responsibility |
| R2➣Rustavi 2 (Georgian TV channel) |
| R2➣Randy River (clothing brand) |
| R2➣Resection of Local Relapsed Tumor |