secondary systemic amyloid

secondary systemic amyloid

Metabolic disease Insoluble protein that is deposited in tissues and organs impairing function Risk factors Myeloma, and conditions lasting 5+ yrs–eg, chronic arthritis, rheumatoid arthritis, SLE, TB, paraplegia, bronchiectasis, cystic fibrosis, osteomyelitis, recurrent pyogenic infection, abscess, decubitus ulcers, renal dialysis, Reiter syndrome, ankylosing spondylitis, Hodgkin's disease, Sjögren syndrome, hairy cell leukemia Clinical Sx reflect organ affected by deposits, compromising its functionality. See Amyloidosis.