paired helical filaments


paired helical filaments

Neuropathology Paired structures that are core constituents of the neurofibrillary tangles of Alzheimer's disease and occur in Down syndrome, Hallervorden-Spatz disease, lead encephalopathy, lipofuscinosis, subacute sclerosing panencephalitis, and tuberous sclerosis. See Alzheimer's disease, Neurofibrillary tangles, Senile plaques.