topoisomerases

Enzymes that assist in the topological manipulation of DNA. Before DNA can replicate it must be unwound. This occurs in short segments and is achieved by a Type I topoisomerase that cuts one strand so that the free end can be rotated around the unbroken strand. Topoisomerase 1 then re-ligates the broken strand. Type II topoisomerases cut both strands. The term is pronounced ‘topo-isomerase’. The derivation is Greek, topos , a place; iso , equal; meros , a part; with the -ase suffix denoting an enzyme.

单词	topoisomerases
释义	topoisomerases topoisomerases [¦tä·pō·ī′säm·ə‚rās·əz] (biochemistry) Any of a group of enzymes capable of relaxing, unwinding, unpackaging, or changing the degree of supercoiling of deoxyribonucleic acid fiber. topoisomerases topoisomerases Enzymes that assist in the topological manipulation of DNA. Before DNA can replicate it must be unwound. This occurs in short segments and is achieved by a Type I topoisomerase that cuts one strand so that the free end can be rotated around the unbroken strand. Topoisomerase 1 then re-ligates the broken strand. Type II topoisomerases cut both strands. The term is pronounced ‘topo-isomerase’. The derivation is Greek, topos , a place; iso , equal; meros , a part; with the -ase suffix denoting an enzyme.
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