terbutaline sulfate

Monovent

Pharmacologic class: Selective beta₂-adrenergic receptor agonist

Therapeutic class: Bronchodilator

Pregnancy risk category B

Action

Relaxes bronchial smooth muscle by stimulating beta₂-adrenergic receptors; inhibits release of hypersensitivity mediators, especially from mast cells

Availability

Injection: 1 mg/ml

Tablets: 2.5 mg, 5 mg

Indications and dosages

➣ Bronchospasm in reversible obstructive airway disease

Adults and children older than age 12: 0.25 mg subcutaneously, repeated in 15 to 30 minutes p.r.n., up to a maximum of 0.5 mg in 4 hours. Or 2.5 to 5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 15 mg/day in adults; 2.5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 7.5 mg/day in children.

Dosage adjustment

• Renal impairment

Off-label uses

• Tocolytic in preterm labor

Contraindications

• Hypersensitivity to drug, its components, or sympathomimetic amines

Precautions

Use cautiously in:

• cardiovascular disorders, hypertension, arrhythmias, hyperthyroidism, diabetes mellitus, seizure disorders, glaucoma

• concurrent use of MAO inhibitors, tricyclic antidepressants, or beta-adrenergic blockers

• elderly patients

• breastfeeding patients.

Administration

• Inject subcutaneously into lateral deltoid.

Adverse reactions

CNS: tremors, anxiety, nervousness, insomnia, headache, dizziness, drowsiness, stimulation

CV: palpitations, chest discomfort, tachycardia

GI: nausea, vomiting

Skin: diaphoresis, flushing

Interactions

Drug-drug. Beta-adrenergic blockers: blockage of bronchodilating effect

MAO inhibitors, tricyclic antidepressants: potentiation of terbutaline's adverse cardiovascular reactions

Other sympathomimetic amines: additive adverse cardiovascular reactions

Patient monitoring

• Monitor vital signs.

• Assess neurologic status.

Patient teaching

• Tell patient he may take with or without food.

• Advise patient or parents to establish effective bedtime routine to minimize insomnia.

• Instruct patient or parents to space doses evenly during waking hours, to avoid taking drug at bedtime.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

Bricanyl

A beta-adrenergic receptor agonist used for patients with COPD.

Indications
Asthma, bronchitis, reversible bronchospasm.

Adverse effects
Tremor, nervousness, palpitations, nausea, vomiting.

单词	terbutaline sulfate
释义	terbutaline sulfate terbutaline sulfate Monovent *Pharmacologic class:* Selective beta₂-adrenergic receptor agonist *Therapeutic class:* Bronchodilator *Pregnancy risk category B* Action Relaxes bronchial smooth muscle by stimulating beta₂-adrenergic receptors; inhibits release of hypersensitivity mediators, especially from mast cells Availability Injection: 1 mg/ml Tablets: 2.5 mg, 5 mg Indications and dosages ➣ Bronchospasm in reversible obstructive airway disease Adults and children older than age 12: 0.25 mg subcutaneously, repeated in 15 to 30 minutes p.r.n., up to a maximum of 0.5 mg in 4 hours. Or 2.5 to 5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 15 mg/day in adults; 2.5 mg P.O. q 6 hours t.i.d. while awake, up to a maximum of 7.5 mg/day in children. Dosage adjustment • Renal impairment Off-label uses • Tocolytic in preterm labor Contraindications • Hypersensitivity to drug, its components, or sympathomimetic amines Precautions Use cautiously in: • cardiovascular disorders, hypertension, arrhythmias, hyperthyroidism, diabetes mellitus, seizure disorders, glaucoma • concurrent use of MAO inhibitors, tricyclic antidepressants, or beta-adrenergic blockers • elderly patients • breastfeeding patients. Administration • Inject subcutaneously into lateral deltoid. Adverse reactions CNS: tremors, anxiety, nervousness, insomnia, headache, dizziness, drowsiness, stimulation CV: palpitations, chest discomfort, tachycardia GI: nausea, vomiting Skin: diaphoresis, flushing Interactions Drug-drug. Beta-adrenergic blockers: blockage of bronchodilating effect MAO inhibitors, tricyclic antidepressants: potentiation of terbutaline's adverse cardiovascular reactions Other sympathomimetic amines: additive adverse cardiovascular reactions Patient monitoring • Monitor vital signs. • Assess neurologic status. Patient teaching • Tell patient he may take with or without food. • Advise patient or parents to establish effective bedtime routine to minimize insomnia. • Instruct patient or parents to space doses evenly during waking hours, to avoid taking drug at bedtime. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above. Bricanyl A beta-adrenergic receptor agonist used for patients with COPD. Indications Asthma, bronchitis, reversible bronchospasm. Adverse effects Tremor, nervousness, palpitations, nausea, vomiting.
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