paracetamol

enUK

ac·et·a·min·o·phen (APAP),

(as-et-ă-mi'nō-fen), An antipyretic and analgesic, with potency similar to that of aspirin. Synonym(s): paracetamol

paracetamol

(păr′ə-sē′tə-môl′, -môl′)n. See acetaminophen.

paracetamol

An over-the-counter analgesic used for headaches, muscle or joint pain, and fever, which lacks anti-inflammatory activity.

Therapeutic range
10–25 mg/L

Critical value
≥ 300 mg/L
Toxicology
Overdose can cause fatal liver failure. Up to 10% of hospitalisations for overdose and 40% of acute hepatic failure are linked to paracetamol overdose, which is more often accidental—e.g., children, alcoholics—than suicidal. Doses of > 150 mg/kg/24 hours cause acute liver failure.
Clinical stage of paracetamol toxicity
1. 1–24 hours—Non-specific.
2. 24–48 hours—Right upper quadrant pain, tenderness with elevated liver enzymes.
3. 72–96 hours—Marked increase in liver enzymes; fulminant hepatic failure, coagulopathy, acidosis.
4. 4–14 days—Liver recuperates or patient dies.
Pathogenesis of paracetamol overdose
90% is metabolised in the liver to non-toxic glucuronide and sulphate conjugates; 5% is oxidised by cytochrome p450 to NAPQI, which covalently binds to hepatocyte macromolecules, leading to hepatocyte death; 5% is excreted unchanged in urine.
Specimen
Blood, urine.

Method
Immunoassay-FPIA.

paracetamol

A drug widely used to relieve pain and reduce fever. The drug does not irritate the stomach, as ASPIRIN does, but overdose causes liver and kidney damage and may cause death from liver failure. 15 g or more is potentially serious. The victim remains well for a day or two and liver failure develops between the third and fifth day. The drug is on the WHO official list. Brand names are Alvedon, Calpol Disprol Paediatric, Infadrops, Medinol and Salzone. Preparations that include paracetamol include Cosalgesic, Distalgesic, Domperamol, Fortagesic, Kapake, Midrid, Migraleve, Paradote, Paramax, Remedeine and Solpadol.

单词	paracetamol
释义	paracetamol enUK par·a·cet·a·mol P5061050 (păr′ə-sē′tə-môl′, -môl′)n. See acetaminophen. paracetamol (ˌpærəˈsiːtəˌmɒl; -ˈsɛtə-) n (Pharmacology) a mild analgesic and antipyretic drug used as an alternative to aspirin. US name: acetaminophen [C20: from para-acetamidophenol] Translations paracétamol I'd like some Tylenol (US) I'd like some paracetamol (UK) → 我要买点扑热息痛 paracetamol enUK paracetamol a mild analgesic and antipyretic drug used as an alternative to aspirin paracetamol enUK ac·et·a·min·o·phen (APAP), (as-et-ă-mi'nō-fen), An antipyretic and analgesic, with potency similar to that of aspirin. Synonym(s): paracetamol paracetamol (păr′ə-sē′tə-môl′, -môl′)n. See acetaminophen. paracetamol An over-the-counter analgesic used for headaches, muscle or joint pain, and fever, which lacks anti-inflammatory activity. Therapeutic range 10–25 mg/L Critical value ≥ 300 mg/L Toxicology Overdose can cause fatal liver failure. Up to 10% of hospitalisations for overdose and 40% of acute hepatic failure are linked to paracetamol overdose, which is more often accidental—e.g., children, alcoholics—than suicidal. Doses of > 150 mg/kg/24 hours cause acute liver failure. Clinical stage of paracetamol toxicity 1. 1–24 hours—Non-specific. 2. 24–48 hours—Right upper quadrant pain, tenderness with elevated liver enzymes. 3. 72–96 hours—Marked increase in liver enzymes; fulminant hepatic failure, coagulopathy, acidosis. 4. 4–14 days—Liver recuperates or patient dies. Pathogenesis of paracetamol overdose 90% is metabolised in the liver to non-toxic glucuronide and sulphate conjugates; 5% is oxidised by cytochrome p450 to NAPQI, which covalently binds to hepatocyte macromolecules, leading to hepatocyte death; 5% is excreted unchanged in urine. Specimen Blood, urine. Method Immunoassay-FPIA. paracetamol A drug widely used to relieve pain and reduce fever. The drug does not irritate the stomach, as ASPIRIN does, but overdose causes liver and kidney damage and may cause death from liver failure. 15 g or more is potentially serious. The victim remains well for a day or two and liver failure develops between the third and fifth day. The drug is on the WHO official list. Brand names are Alvedon, Calpol Disprol Paediatric, Infadrops, Medinol and Salzone. Preparations that include paracetamol include Cosalgesic, Distalgesic, Domperamol, Fortagesic, Kapake, Midrid, Migraleve, Paradote, Paramax, Remedeine and Solpadol. AcronymsSeePCThesaurusSeeacetaminophen
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paracetamol

par·a·cet·a·mol

paracetamol

paracetamol

paracetamol

paracetamol

ac·et·a·min·o·phen (APAP),

paracetamol

paracetamol

paracetamol