paraganglioma


paraganglioma

 [par″ah-gang″gle-o´mah] a tumor of the tissue composing the paraganglia.

par·a·gan·gli·o·ma

(par'ă-gang'glē-ō'mă), A neoplasm usually derived from the chemoreceptor tissue of a paraganglion, such as the carotid body, or the medulla of the adrenal gland; the latter is usually termed a chromaffinoma or pheochromocytoma.

paraganglioma

An uncommon neuroendocrine tumour often of the head and neck which arises in neural crest and is more common in women; 2 to 9% of carotid body, vagal body and jugulo-tympanic paragangliomas are malignant vs. 25% of those in the larynx. Paragangliomas are part of Carney’s triad (extraadrenal paraganglioma, GIST, pulmonary chondroma), and occur in von Hippel-Lindau syndrome..
 
Clinical findings
Pulsatile mass, tinnitus.
Sites
Carotid body (60%), jugulotympanic, glomus vagale.
DiffDx
Neuroendocrine tumours—e.g., carcinoid, haemangiopericytoma, neuroendocrine carcinoma, medullary carcinoma of thyroid, middle ear adenoma, meningioma.

paraganglioma

Oncology A head & neck neural crest tumor more common in ♀; 2-9% of PGs in carotid body, vagal body and jugulo-tympanic region are malignant; 25% of laryngeal PGs are malignant. See Zellballen.

par·a·gan·gli·o·ma

(par'ă-gang-glē-ō'mă) A neoplasm usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or the medulla of the suprarenal gland; the latter is usually termed a chromaffinoma or pheochromocytoma.

par·a·gan·gli·o·ma

(par'ă-gang-glē-ō'mă) A neoplasm usually derived from the chromoreceptor tissue of a paraganglion or the medulla of the suprarenal gland.