Rogaine
Ro·gaine
R0284750 (rō′gān′)| Noun | 1. |  Rogaine - a vasodilator (trade name Loniten) used to treat severe hypertension; one side effect is hirsutism so it is also sold (trade name Rogaine) as a treatment for male-patterned baldness |
Rogaine
minoxidil
Pharmacologic class: Peripheral vasodilator (direct-acting)
Therapeutic class: Antihypertensive, hair growth stimulant
Pregnancy risk category C
FDA Box Warning
• Drug may cause serious adverse effects (such as pericardial effusion occasionally progressing to tamponade) and may exacerbate angina pectoris. Reserve it for hypertensive patients who respond inadequately to maximum therapeutic doses of diuretic and two other antihypertensives.
• Give under close supervision, usually concurrently with therapeutic doses of beta blocker to prevent tachycardia and increased myocardial workload. Usually, drug also must be given with diuretic to prevent serious fluid accumulation. Patients with malignant hypertension and those already receiving guanethidine should be hospitalized when therapy begins so they can be monitored to avoid too rapid, or large orthostatic, blood pressure decreases.
Action
Reduces blood pressure by relaxing vascular smooth muscle, causing vasodilation. Action in hair growth stimulation unclear; vasodilatory action may enhance microcirculation around hair follicles.
Availability
Tablets: 2.5 mg, 10 mg
Topical solution: 2%, 5%
Indications and dosages
➣ Severe symptomatic hypertension; hypertension associated with end-organ damage
Adults and children ages 12 and older: 5 mg/day as a single dose, increased carefully q 3 days. Usual range is 10 to 40 mg/day in single or divided doses. For rapid blood pressure control with careful monitoring, dosage may be adjusted q 6 hr. Maximum dosage is 100 mg/day.
Children younger than age 12: 0.2 mg/kg/day P.O. as a single dose. May increase in increments of 50% to 100% until blood pressure control is optimal. Usual range is 0.25 to 1 mg/kg/day; maximum recommended dosage is 50 mg/day.
➣ Male-pattern baldness; diffuse hair loss or thinning in women; adjunct to hair transplantation
Adults: Apply 1 ml of 2% or 5% topical solution to affected area b.i.d. for 4 months or longer.
➣ Alopecia areata
Adults: Apply 1 ml of 2% or 5% topical solution to scalp b.i.d.
Contraindications
• Hypersensitivity to drug or its components
• Dissecting aortic aneurysm
• Pheochromocytoma
Precautions
Use cautiously in:
• recent MI, malignant hypertension, heart failure, angina pectoris, severe renal impairment
• concurrent guanethidine therapy
• pregnant or breastfeeding patients.
Administration
• Give oral form with meals to decrease GI upset.
See If patient is also receiving guanethidine, discontinue that drug 1 to 3 days before starting minoxidil, to avoid severe orthostatic hypotension.
• Know that oral form is usually given with a beta-adrenergic blocker or diuretic to control hypertension.
Adverse reactions
CV: ECG changes (such as T-wave changes), tachycardia, angina, pericardial effusion, cardiac tamponade, heart failure
GI: nausea, vomiting
Respiratory: pulmonary edema
Skin: hypertrichosis
Other: weight gain, edema
Interactions
Drug-drug. Antihypertensives, nitrates: additive hypotension
Guanethidine: severe orthostatic hypotension
Nonsteroidal anti-inflammatory drugs: decreased minoxidil efficacy
Drug-diagnostic tests. Alkaline phosphatase, blood urea nitrogen, creatinine, plasma renin activity, sodium: increased levels
Hematocrit, hemoglobin, red blood cells: decreased levels
Patient monitoring
• Monitor vital signs and ECG.
• Assess daily weight and fluid intake and output.
See Monitor cardiovascular status carefully. Stay alert for signs and symptoms of heart failure.
• Watch for hypertrichosis.
• Know that hematologic and renal values usually return to pretreatment levels with continued therapy.
Patient teaching
• Instruct patient to take oral form with meals to decrease GI upset.
• Advise patient to weigh himself daily and report sudden gains.
• Tell patient taking oral form that drug may darken, lengthen, and thicken body hair. Tell him to shave or use depilatory to reduce unwanted hair growth. Reassure him that unwanted growth will disappear 1 to 6 months after he stops taking drug.
See Instruct patient to immediately report difficulty breathing (especially when lying down) or pain in chest, arm, or shoulder.
• Teach patient how to use topical form. Urge him to read package insert carefully.
• Caution patient not to use topical form on other body parts and not to let it contact mucous membranes.
• Tell patient using topical form that new scalp hair will be soft and barely visible. Caution him to use only 1 ml twice daily, regardless of amount of balding. Remind him not to stop using drug suddenly, because new hair growth will be lost.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.
Rogaine
(rō′gān′)Patient discussion about Rogaine
Q. Is their a drug available to regain my energy back from having hypothyrodiam? I was diagnosed three years ago with Hypothyroidism. I have been using medication to level out my thyroid level. The lack of energy and weakness I am experiencing at the age of 42 is maddening. I want my life back the way it was. I am tired of feeling tired and zombie like.
You can always ask for more information about your condition: whether it's primary or secondary hypothyroidism and what may/may not have caused it, or what you can do to improve your symptoms.
ROGAINE
| Acronym | Definition |
|---|---|
| ROGAINE |
Rogaine
- noun
Synonyms for Rogaine
noun a vasodilator (trade name Loniten) used to treat severe hypertension
Synonyms
- Loniten
- minoxidil
Related Words
- vasodilative
- vasodilator