bay region

The site on benzo[a]pyrene, an indirect carcinogen which is metabolically activated by the P-450 cytochrome oxidase system.
Specifically, at the 7,8 double bond, leading to a 7,8 oxide, which is rapidly converted to a 7,8-dihydrodiol and later epoxidated near the bay region at the 9,10 double bond; the resulting product, a diol-epoxide, is a poor substrate for epoxide hydratase and is released from the mitochondria into the cell as a highly reactive electrophil, becoming an “ultimate” carcinogen, as it reacts with negative charges in DNA; P-450 reactions at the K region yield a non-reactive non-carcinogenic inert molecule.

单词	bay region
释义	bay region bay region The site on benzo[a]pyrene, an indirect carcinogen which is metabolically activated by the P-450 cytochrome oxidase system. Specifically, at the 7,8 double bond, leading to a 7,8 oxide, which is rapidly converted to a 7,8-dihydrodiol and later epoxidated near the bay region at the 9,10 double bond; the resulting product, a diol-epoxide, is a poor substrate for epoxide hydratase and is released from the mitochondria into the cell as a highly reactive electrophil, becoming an “ultimate” carcinogen, as it reacts with negative charges in DNA; P-450 reactions at the K region yield a non-reactive non-carcinogenic inert molecule.
随便看	external interface external interface assembly external interface data table external interface engine external interface file external interface manager external interface requirements specification external interface rights description table external interface specification external interface testing external interface unit external interrupt external interrupt control register external interrupt control register a external interrupt control register b external interrupt enable external interrupt enable mask external interrupt flag register external interrupt handler external interrupt pending register external interrupt request external interrupt request fault external-interrupt status word external ip address externalisation