thrombopoietin


thrombopoietin

 [throm″bo-poi´ĕ-tin] a colony-stimulating factor that is the humoral regulator of the production of platelets.

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin), [MIM*600044] A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1. Synonym(s): megakaryocyte growth and development factor, megapoietin [thrombo- + G. poiētēs, maker, + in]

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin) A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
Synonym(s): megakaryocyte growth and development factor, megapoietin. [thrombo- + G. poiētēs, maker, + in]

thrombopoietin

A hormone responsible for the growth of colonies of megakaryocytes and the production of platelets. The existence of thrombopoietin has been suspected for 30 years but was realized only in 1994. In 1997 the results of a trial of polyethylene-conjugated genetically-engineered (recombinant) thrombopoietin-described as recombinant human megakatyocyte growth and development factor (PEGrHuMGDF)-was published. It was found to have a powerful stimulatory effect on PLATELET production. Thrombopoietin is the ligand for the cytokine receptor Mpl.