| 单词 | atrogin-1 |
| 释义 | atrogin-1atrogin-1An E3 ubiquitin ligase expressed in cardiac and skeletal muscle that directs muscle protein degradation after the muscle atrophy response has been triggered by Akt1-induced phosphorylation of FOXO, a transcription factor which also activates ubiquitin ligases and MuRF-1. Atrogin-deficient mice are resistant to muscle atrophy. |
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