atrophic gastritis

gastritis

[gas-tri´tis] inflammation of the lining of the stomach. Gastritis is one of the most common stomach disorders, and occurs in acute, chronic, and toxic forms.acute gastritis severe gastritis that may be caused by intake of aspirin or other nonsteroidal antiinflammatory drugs, food poisoning, overeating, excessive intake of alcoholic beverages, or bacterial or viral infection; it is often accompanied by enteritis. The outstanding symptom is abdominal pain, and there is also a feeling of distention, with loss of appetite and nausea. There may be a slight fever and vomiting. The substance causing the irritation can often be identified, in which case it should be avoided. Treatment may include the use of antacids. A bland diet of liquids and easily digested food should be followed for 2 or 3 days. Simply prepared solid foods in small quantities can then be added.atrophic gastritis chronic gastritis with atrophy of the mucous membranes and glands.chronic gastritis gastritis that occurs repeatedly or continues over a period of time. Although pain, especially after eating, and symptoms associated with indigestion may occur in chronic gastritis, most patients are asymptomatic; however, the condition may lead to hemorrhage and ulcer formation. Among its possible causes are Helicobacter pylori, vitamin deficiencies, abnormalities of the gastric juice, ulcers, hiatus hernia, excessive use of alcohol, or a combination of any of these.
Chronic gastritis is treated with a bland diet; food should be taken frequently and in small amounts. Antacids or anticholinergics may also be used in moderation to minimize stomach acidity. If bleeding is a problem that cannot be controlled by conservative measures, partial gastrectomy, pyloroplasty, vagotomy, or total gastrectomy may be indicated.giant hypertrophic gastritis Ménétrier's disease.toxic gastritis gastritis resulting from ingestion of a corrosive substance such as a strong acid or poison. There is an acute burning sensation and cramping stomach pain, accompanied by diarrhea and vomiting; the vomit may be bloody. The victim may collapse. This condition is an emergency and immediate measures must be taken to prevent serious damage to the tissues of the stomach. First aid measures are begun at once to flush out and neutralize the poison.

a·troph·ic gas·tri·tis

chronic gastritis with atrophy of the mucous membrane and destruction of the peptic glands, sometimes associated with pernicious anemia or gastric carcinoma; also applied to gastric atrophy without inflammatory changes.

atrophic gastritis

A type of chronic gastritis, which is characterised by inflammatory destruction of specialised parietal and chief cell zones, leading to atrophy, mucus neck cell metaplasia, intestinal metaplasia and pancreatic acinar metaplasia, which may lead to the development of type-1 ECL-cell tumours (gastric carcinoids).
Pathogenesis
Chronic corpus gastritis and autoimmune gastritis leads to hypochlorhydria, then hypergastrinaemia, then ECL-cell hyperplasia (first linear and then micronodular), then adenomatoid hyperplasia (> 5 micronodules), then ECL dysplasia, and finally to carcinoid tumour (> 0.5 mm or submucosal invasion). Reduced acidity, either surgically by vagotomy or pharmacologically by cimetidine, results in functional atrophy, changing the stomach’s flora to bugs that form N-nitroso compounds. Atrophic gastritis may be a common pathway for gastric ulcers and cancer in patients with H pylori infection.

atrophic gastritis

Gastroentrology A condition that is the end result of chronic gastritis, characterized by mucosal atrophy, which may be a precursor of gastric CA. See Helicobacter pylori, Stomach cancer.

a·troph·ic gas·tri·tis

(ā-trō'fik gas-trī'tis) Chronic gastritis with atrophy of the mucous membrane and destruction of the peptic glands, sometimes associated with pernicious anemia or gastric carcinoma; also applied to gastric atrophy without inflammatory changes.

atrophic gastritis

Long-term (chronic) inflammation of the stomach with atrophy of the lining mucous membrane and poor or absent secretion of acid, PEPSIN and the INTRINSIC FACTOR. Loss of the intrinsic factor leads to PERNICIOUS ANAEMIA.

单词	atrophic gastritis
释义	DictionarySeegastritis atrophic gastritis atrophic gastritis [ā′trōf·ik gas′trīd·əs] (medicine) Chronic inflammation of the stomach with atrophy of the mucosa. atrophic gastritis gastritis [gas-tri´tis] inflammation of the lining of the stomach. Gastritis is one of the most common stomach disorders, and occurs in acute, chronic, and toxic forms.acute gastritis severe gastritis that may be caused by intake of aspirin or other nonsteroidal antiinflammatory drugs, food poisoning, overeating, excessive intake of alcoholic beverages, or bacterial or viral infection; it is often accompanied by enteritis. The outstanding symptom is abdominal pain, and there is also a feeling of distention, with loss of appetite and nausea. There may be a slight fever and vomiting. The substance causing the irritation can often be identified, in which case it should be avoided. Treatment may include the use of antacids. A bland diet of liquids and easily digested food should be followed for 2 or 3 days. Simply prepared solid foods in small quantities can then be added.atrophic gastritis chronic gastritis with atrophy of the mucous membranes and glands.chronic gastritis gastritis that occurs repeatedly or continues over a period of time. Although pain, especially after eating, and symptoms associated with indigestion may occur in chronic gastritis, most patients are asymptomatic; however, the condition may lead to hemorrhage and ulcer formation. Among its possible causes are Helicobacter pylori, vitamin deficiencies, abnormalities of the gastric juice, ulcers, hiatus hernia, excessive use of alcohol, or a combination of any of these. Chronic gastritis is treated with a bland diet; food should be taken frequently and in small amounts. Antacids or anticholinergics may also be used in moderation to minimize stomach acidity. If bleeding is a problem that cannot be controlled by conservative measures, partial gastrectomy, pyloroplasty, vagotomy, or total gastrectomy may be indicated.giant hypertrophic gastritis Ménétrier's disease.toxic gastritis gastritis resulting from ingestion of a corrosive substance such as a strong acid or poison. There is an acute burning sensation and cramping stomach pain, accompanied by diarrhea and vomiting; the vomit may be bloody. The victim may collapse. This condition is an emergency and immediate measures must be taken to prevent serious damage to the tissues of the stomach. First aid measures are begun at once to flush out and neutralize the poison. a·troph·ic gas·tri·tis chronic gastritis with atrophy of the mucous membrane and destruction of the peptic glands, sometimes associated with pernicious anemia or gastric carcinoma; also applied to gastric atrophy without inflammatory changes. atrophic gastritis A type of chronic gastritis, which is characterised by inflammatory destruction of specialised parietal and chief cell zones, leading to atrophy, mucus neck cell metaplasia, intestinal metaplasia and pancreatic acinar metaplasia, which may lead to the development of type-1 ECL-cell tumours (gastric carcinoids). Pathogenesis Chronic corpus gastritis and autoimmune gastritis leads to hypochlorhydria, then hypergastrinaemia, then ECL-cell hyperplasia (first linear and then micronodular), then adenomatoid hyperplasia (> 5 micronodules), then ECL dysplasia, and finally to carcinoid tumour (> 0.5 mm or submucosal invasion). Reduced acidity, either surgically by vagotomy or pharmacologically by cimetidine, results in functional atrophy, changing the stomach’s flora to bugs that form N-nitroso compounds. Atrophic gastritis may be a common pathway for gastric ulcers and cancer in patients with H pylori infection. atrophic gastritis Gastroentrology A condition that is the end result of chronic gastritis, characterized by mucosal atrophy, which may be a precursor of gastric CA. See Helicobacter pylori, Stomach cancer. a·troph·ic gas·tri·tis (ā-trō'fik gas-trī'tis) Chronic gastritis with atrophy of the mucous membrane and destruction of the peptic glands, sometimes associated with pernicious anemia or gastric carcinoma; also applied to gastric atrophy without inflammatory changes. atrophic gastritis Long-term (chronic) inflammation of the stomach with atrophy of the lining mucous membrane and poor or absent secretion of acid, PEPSIN and the INTRINSIC FACTOR. Loss of the intrinsic factor leads to PERNICIOUS ANAEMIA.
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