SMAD5

SMAD5

A gene on chromosome 5q31 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD5 is a receptor-regulated SMAD (R-SMAD) transcriptional modulator activated by bone morphogenetic protein (BMP) type-1 receptor kinase.