SMAD7

A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Once bound, the complex translocates to the cytoplasm, where it inhibits TGF(transforming growth factor)-beta and activin signalling by associating with their receptors, preventing SMAD2 access.

Molecular pathology
SMAD7 variants have an increased susceptibility to colorectal cancer type 3.

单词	smad7
释义	SMAD7 SMAD7 A gene on chromosome 18q21.1 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (MAD), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Once bound, the complex translocates to the cytoplasm, where it inhibits TGF(transforming growth factor)-beta and activin signalling by associating with their receptors, preventing SMAD2 access. Molecular pathology SMAD7 variants have an increased susceptibility to colorectal cancer type 3.
随便看	anterior surface of maxilla anterior surface of patella anterior surface of petrous part of temporal bone anterior surface of prostate anterior surface of radius anterior surface of scapula anterior surface of suprarenal gland anterior surface of thigh anterior surface of ulna anterior surface of uterus anterior symblepharon anterior synechia anterior talar articular surface of calcaneus anterior talofibular anterior talofibular ligament anterior talotibial ligament anterior tarsal syndrome anterior tarsal tendinous sheaths anterior teeth anterior teeth selection anterior tegmental decussation anterior telencephalon anterior temporal anterior temporal artery anterior temporal branch