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thyroglobulin
thy·ro·glob·u·lin T0199950 (thī′rō-glŏb′yə-lĭn)n.1. A thyroid protein that assists in the synthesis of the iodine-containing hormones thyroxine and triiodothyronine and is typically present in the colloid of thyroid gland follicles.2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.thyroglobulin (ˌθaɪrəʊˈɡlɒbjʊlɪn) n (Biology) a protein which is found in the thyroid gland and which contains iodineThesaurus| Noun | 1. | thyroglobulin - an iodine containing protein that is obtained from the thyroid gland and exhibits the general properties of the globulinsiodinated protein, iodoprotein - a protein that contains iodine |
TranslationsThyroglobulin
thyroglobulin[¦thī·rō′gläb·yə·lən] (biochemistry) An iodinated protein found as the storage form of the iodinated hormones in the thyroid follicular lumen and epithelial cells. Thyroglobulin a glycoprotein produced by the follicles of the thyroid gland; a direct precursor of the thyroid hormones. The carbohydrate and protein constituents of thyroglobulin are synthesized in the ribosomes of the thyroid epithelium. Subsequent iodination of the residues of the amino acid tyrosine, which are part of the thyroglobulin molecule, results in the formation of thyroxine and triiodothyronine. These are released into the blood after splitting off from thyroglobulin under the influence of the proteolytic enzymes of the thyroid gland. The cells’ ability to iodinate thyroglobulin arises after the appearance of the endoplasmic reticulum in the gland, the formation of follicles, and the secretion of thyrotropin by the hypophysis. thyroglobulin
thyroglobulin [thi´ro-glob″u-lin] an iodine-containing glycoprotein of high molecular weight found in the colloid of the follicles of the thyroid gland; its iodinated tyrosine moieties form the active hormones thyroxine and triiodothyronine.thy·ro·glob·u·lin (thī'rō-glob'yū-lin), [MIM*188450] 1. A protein that contains precursors of thyroid hormone usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein and the combination of two iodotyrosines to form thyroxine, the fully iodinated thyronine; secretion of thyroid hormone requires proteolytic degradation of thyroglobulin, with the attendant release of free hormone; a defect in thyroglobulin metabolism will lead to hypothyroidism. Synonym(s): iodoglobulin, thyroprotein (1) 2. A substance obtained by the fractionation of thyroid glands from the hog, Sus scrofa, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism. thyroglobulin (thī′rō-glŏb′yə-lĭn)n.1. A thyroid protein that is the precursor to iodine-containing hormones and is typically present in the colloid of thyroid gland follicles.2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.thyroglobulin A 669 kD iodine-rich glycoprotein secreted by thyroid follicular cells into thyroid colloid where it is iodinated; once resorbed by follicular cells, it is cleaved into multiple units of T3–iodothyronine and T4–thyroxine. See T3, T4, Thyroid gland.thy·ro·glob·u·lin (thī'rō-glob'yū-lin) 1. A protein that contains thyroid hormone, usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein. A defect in thyroglobulin will lead to hypothyroidism. 2. A substance obtained by the fractionation of thyroid glands from pigs, Sus scrofula, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Compare: bioregulatorthyroglobulin A large protein molecule, the storage form and precursor of the thyroid gland hormones.thyroglobulin a protein that contains and stores THYROXINE and triiodo-thyroxine in the THYROID GLAND.FinancialSeeTGAcronymsSeethank godthyroglobulin
Words related to thyroglobulinnoun an iodine containing protein that is obtained from the thyroid gland and exhibits the general properties of the globulinsRelated Words- iodinated protein
- iodoprotein
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