serpin


serpin

 [ser´pin] any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissues; all are similarly structured single-chain glycoproteins although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha1-antitrypsin, antithrombin III, antiplasmin" >α2-antiplasmin, inhibitor" >C1 inhibitor, and inhibitor 1" >plasminogen activator inhibitor 1 (PAI-1). Called also serine protease or proteinase inhibitor.

serpin

DRV-1236741938 (ser′pĭn) [ ser(ine) + p(roteinase) + in(hibitor)] A serine protease inhibitor.