tamsulosin hydrochloride

Bazetham, Contiflo XL, Flomax, Flomax CR, Flomaxtra, Novo-Tamsulosin, Omnic MR, Ran-TamsulosinW, Ratio-Tamsulosin, Sandoz Tamsulosin, Stronazon, Tabphyn

Pharmacologic class: Alpha-adrenergic blocker

Therapeutic class: Anti-adrenergic

Pregnancy risk category B

Action

Decreases smooth muscle contractions of prostate by binding to alpha₁-adrenergic receptors. This action increases urine flow and reduces symptoms of benign prostatic hyperplasia (BPH).

Availability

Capsules: 0.4 mg

Indications and dosages

➣ BPH

Adults: 0.4 mg/day P.O. after a meal. After 2 to 4 weeks, may increase to 0.8 mg/day.

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• concurrent use of other alpha-adrenergic blockers or strong CYP3A4 inhibitors (avoid use)

• concurrent use of moderate CYP3A4 inhibitors, strong or moderate CYP2D6 inhibitors, other cytochrome P450 inhibitors, warfarin, and in patients who are poor CYP2D6 metabolizers

• patients at increased risk for prostate cancer.

Administration

• Give 30 minutes after same meal each day.

Adverse reactions

CNS: dizziness, headache, asthenia, insomnia, drowsiness, syncope, vertigo

CV: orthostatic hypotension, chest pain

EENT: rhinitis, amblyopia, pharyngitis, sinusitis

GU: retrograde or diminished ejaculation, decreased libido

Musculoskeletal: back pain

Respiratory: increased cough

Other: tooth disorder, infection

Interactions

Drug-drug. Cimetidine: increased tamsulosin blood level, greater risk of toxicity

Doxazosin, prazosin, terazosin: increased risk of hypotension

Ketoconazole (strong CYP3A4 inhibitor), paroxetine (strong CYP2D6 inhibitor): increased tamsulosin C_max and area under the curve

Drug-behaviors. Alcohol use: increased risk of hypotension

Patient monitoring

• Monitor blood pressure. Stay alert for orthostatic hypotension.

Patient teaching

• Tell patient to take 30 minutes after same meal each day.

• Instruct patient not to chew or open capsule. Advise him to swallow it whole.

• Tell patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from sudden blood pressure decrease.

• Caution patient to avoid hazardous activities on first day of therapy.

• Inform patient that drug may cause abnormal ejaculation. Advise him to discuss this issue with prescriber.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and behaviors mentioned above.

单词	tamsulosin hydrochloride
释义	DictionarySeetamsulosin tamsulosin hydrochloride tamsulosin hydrochloride Bazetham, Contiflo XL, Flomax, Flomax CR, Flomaxtra, Novo-Tamsulosin, Omnic MR, Ran-TamsulosinW, Ratio-Tamsulosin, Sandoz Tamsulosin, Stronazon, Tabphyn *Pharmacologic class:* Alpha-adrenergic blocker *Therapeutic class:* Anti-adrenergic *Pregnancy risk category B* Action Decreases smooth muscle contractions of prostate by binding to alpha₁-adrenergic receptors. This action increases urine flow and reduces symptoms of benign prostatic hyperplasia (BPH). Availability Capsules: 0.4 mg Indications and dosages ➣ BPH Adults: 0.4 mg/day P.O. after a meal. After 2 to 4 weeks, may increase to 0.8 mg/day. Contraindications • Hypersensitivity to drug or its components Precautions Use cautiously in: • concurrent use of other alpha-adrenergic blockers or strong CYP3A4 inhibitors (avoid use) • concurrent use of moderate CYP3A4 inhibitors, strong or moderate CYP2D6 inhibitors, other cytochrome P450 inhibitors, warfarin, and in patients who are poor CYP2D6 metabolizers • patients at increased risk for prostate cancer. Administration • Give 30 minutes after same meal each day. Adverse reactions CNS: dizziness, headache, asthenia, insomnia, drowsiness, syncope, vertigo CV: orthostatic hypotension, chest pain EENT: rhinitis, amblyopia, pharyngitis, sinusitis GU: retrograde or diminished ejaculation, decreased libido Musculoskeletal: back pain Respiratory: increased cough Other: tooth disorder, infection Interactions Drug-drug. Cimetidine: increased tamsulosin blood level, greater risk of toxicity Doxazosin, prazosin, terazosin: increased risk of hypotension Ketoconazole (strong CYP3A4 inhibitor), paroxetine (strong CYP2D6 inhibitor): increased tamsulosin C_max and area under the curve Drug-behaviors. Alcohol use: increased risk of hypotension Patient monitoring • Monitor blood pressure. Stay alert for orthostatic hypotension. Patient teaching • Tell patient to take 30 minutes after same meal each day. • Instruct patient not to chew or open capsule. Advise him to swallow it whole. • Tell patient to move slowly when sitting up or standing, to avoid dizziness or light-headedness from sudden blood pressure decrease. • Caution patient to avoid hazardous activities on first day of therapy. • Inform patient that drug may cause abnormal ejaculation. Advise him to discuss this issue with prescriber. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and behaviors mentioned above.
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