properdin

(prō`pərdən), protein found in the blood serum of humans and some of the higher animals that appears to participate in certain specific immune responses. It is associated with the engulfing of foreign particles and invading cells by phagocytes and with tissue inflammation (see bloodblood,
fluid pumped by the heart that circulates throughout the body via the arteries, veins, and capillaries (see circulatory system; heart). An adult male of average size normally has about 6 quarts (5.6 liters) of blood.
..... Click the link for more information. ; immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information. ). Properdin has been isolated in highly purified form.

Properdin

in mammals, a protein in blood serum, one of the globulins and one of the factors of natural immunity. Properdin participates in destroying bacteria and protozoans, neutralizing viruses, and stimulating phagocytosis either independently or by activating the complement system.

In man, properdin is a homogeneous protein detected electrophoretically in the beta-globulin region; its molecular weight is 223,000. In a healthy person, 1 milliliter of blood contains 2.5—8 micrograms of properdin nitrogen. Properdin content decreases with burns, after irradiation, and with malignant neoplasms; it increases with the introduction of bacterial endotoxins.

Properdin differs functionally and antigenetically from immunoglobulins and complement factors. It is a part of the properdin system, a special system of serum proteins that function together; the system was discovered in 1954 by the American scientist L. Pillemer and his colleagues. The properdin system includes properdin, factor A (a protein inactivated by hydrazine), factor B (a β-glycoprotein with an increased content of glycine), and an Mg²⁺ ion.

REFERENCES

Chernokhvostova, E. V. “Sistema properdina.” In L. S. Reznikova, Komplement i ego znachenie v immunologicheskikh reaktsiiakh. Moscow, 1967. Pages 157–84.
“Properties of Highly Purified Human Properdin.” Journal of Immunology, 1968, vol. 100, no. 1.

A. N. MATS

properdin

[′prō·pər·dən] (immunology) A macroglobin of normal plasma capable of killing various bacteria and viruses in the presence of complement and magnesium ions.

properdin

[pro´per-din] a protein of the alternative complement pathway, augmenting complement activation. Called also factor P.

pro·per·din

(prō'per-din), A control protein for the alternate complement cascade, properdin stabilizes the C₃ convertase enzyme, a deficiency of which increases susceptibility to systemic meningococcal infections and can be inherited in an x-linked pattern.
See also: properdin system, component of complement, factor P. [pro- + L. perdo, to destroy]

properdin

(prō-pûr′dn)n. A protein in blood serum that is a component of the innate immune system, acting as a positive regulator of the alternative pathway of the complement system.

pro·per·din

(prō'pĕr-din) A group of proteins involved in resistance to infection that participate, in conjunction with other factors, in an alternate pathway to the activation of the terminal components of complement.
See also: properdin system, component of complement[pro- + L. perdo, to destroy]

单词	properdin
释义	properdin pro·per·din P0599200 (prō-pûr′dn)n. A protein in blood serum that is a component of the innate immune system, acting as a positive regulator of the alternative pathway of the complement system. [Probably pro- + Latin perdere, to destroy; see perdition + -in.] properdin (ˈprəʊpədɪn) n (Medicine) immunol a protein present in blood serum that, acting with complement, is involved in the destruction of alien cells, such as bacteria properdin properdin (prō`pərdən), protein found in the blood serum of humans and some of the higher animals that appears to participate in certain specific immune responses. It is associated with the engulfing of foreign particles and invading cells by phagocytes and with tissue inflammation (see bloodblood, fluid pumped by the heart that circulates throughout the body via the arteries, veins, and capillaries (see circulatory system; heart). An adult male of average size normally has about 6 quarts (5.6 liters) of blood. ..... Click the link for more information. ; immunityimmunity, ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity. ..... Click the link for more information. ). Properdin has been isolated in highly purified form. Properdin in mammals, a protein in blood serum, one of the globulins and one of the factors of natural immunity. Properdin participates in destroying bacteria and protozoans, neutralizing viruses, and stimulating phagocytosis either independently or by activating the complement system. In man, properdin is a homogeneous protein detected electrophoretically in the beta-globulin region; its molecular weight is 223,000. In a healthy person, 1 milliliter of blood contains 2.5—8 micrograms of properdin nitrogen. Properdin content decreases with burns, after irradiation, and with malignant neoplasms; it increases with the introduction of bacterial endotoxins. Properdin differs functionally and antigenetically from immunoglobulins and complement factors. It is a part of the properdin system, a special system of serum proteins that function together; the system was discovered in 1954 by the American scientist L. Pillemer and his colleagues. The properdin system includes properdin, factor A (a protein inactivated by hydrazine), factor B (a β-glycoprotein with an increased content of glycine), and an Mg²⁺ ion. REFERENCES Chernokhvostova, E. V. “Sistema properdina.” In L. S. Reznikova, Komplement i ego znachenie v immunologicheskikh reaktsiiakh. Moscow, 1967. Pages 157–84. “Properties of Highly Purified Human Properdin.” Journal of Immunology, 1968, vol. 100, no. 1. A. N. MATS properdin [′prō·pər·dən] (immunology) A macroglobin of normal plasma capable of killing various bacteria and viruses in the presence of complement and magnesium ions. properdin properdin [pro´per-din] a protein of the alternative complement pathway, augmenting complement activation. Called also factor P. pro·per·din (prō'per-din), A control protein for the alternate complement cascade, properdin stabilizes the C₃ convertase enzyme, a deficiency of which increases susceptibility to systemic meningococcal infections and can be inherited in an x-linked pattern. See also: properdin system, component of complement, factor P. [pro- + L. perdo, to destroy] properdin (prō-pûr′dn)n. A protein in blood serum that is a component of the innate immune system, acting as a positive regulator of the alternative pathway of the complement system. pro·per·din (prō'pĕr-din) A group of proteins involved in resistance to infection that participate, in conjunction with other factors, in an alternate pathway to the activation of the terminal components of complement. See also: properdin system, component of complement[pro- + L. perdo, to destroy]
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