| 释义 |
afibrinogenemiaenUK
Thesaurus| Noun | 1. |  afibrinogenemia - the absence of fibrinogen in the plasma leading to prolonged bleedingcongenital afibrinogenemia - a rare congenital disorder of blood coagulation in which no fibrinogen is found in the blood plasmablood disease, blood disorder - a disease or disorder of the blood |
TranslationsafibrinogenemiaenUK
afibrinogenemia[‚ā·fī¦brin·ə·jə′nē·mē·ə] (medicine) Complete absence of fibrinogen in the blood. afibrinogenemiaenUK
afibrinogenemia [a″fi-brin″o-jĕ-ne´me-ah] absence or deficiency of fibrinogen" >fibrinogen in the circulating blood. Congenital afibrinogenemia (complete absence of fibrinogen) is a rare anomaly that is inherited. Acquired afibrinogenemia is actually a deficiency of fibrinogen (hypofibrinogenemia) and often is a serious complication in obstetrics, the primary cause being excessive maternal use of fibrinogen during an abnormal pregnancy. The condition may be seen in association with malignancies of the bone and prostate and with leukemia. It also may follow transfusion of incompatible blood and sometimes may complicate thoracic and abdominal surgery.Symptoms. As would be expected in a deficiency of fibrinogen, which plays an important role in the blood clotting mechanism, the chief symptom is generalized bleeding, external or internal. In obstetric or surgical patients suffering from this condition there is frequently sudden and uncontrollable hemorrhage.Treatment. Fibrinogen is administered intravenously to supply the body with this essential substance; transfusions of plasma" >fresh frozen plasma or cryoprecipitate may also be indicated. In patients with cancer of the prostate the fibrinogen level often returns to normal after administration of estrogens. In obstetric patients the fibrinogen level returns to normal after the uterus has been emptied.a·fi·brin·o·gen·e·mi·a (ā-fī'brin-ō-jĕ-nē'mē-ă), The absence of fibrinogen in the plasma.
See also: hypofibrinogenemia. afibrinogenemia A rare autosomal recessive MIM 202400 condition characterised by completely incoagulable blood, which may be first identified by excess bleeding from the infant’s umbilical stump; other findings include bone and liver lesions, and spontaneous rupture of spleen. Postnatal fitness is essentially zero. Symptomatic carriers respond well to prophylactic or prn fibrinogen replacement therapy, either prophylactically or on demand. Consanguinity is a given and occurs in Jewish people, with uncle-niece pairings reported in Israel and permutations thereof in Iraqis and Moroccans.
Molecular pathology
Deletion mutation of FGA on chromosome 4q28.afibrinogenemia Hematology A rare AR condition characterized by complete incoagulability of blood, which may be first identified by excess bleeding from the umbilical stump; other findings include bone and liver lesions, and spontaneous rupture of spleena·fi·brin·o·gen·e·mia (ā-fī'brin-ō-jĕ-nē'mē-ă) The absence of fibrinogen in the plasma.
See also: hypofibrinogenemia
Synonym(s): afibrinogenaemia. afibrinogenemiaenUK
Related to afibrinogenemia: hypofibrinogenemia, dysfibrinogenemiaWords related to afibrinogenemianoun the absence of fibrinogen in the plasma leading to prolonged bleedingRelated Words- congenital afibrinogenemia
- blood disease
- blood disorder
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